ACVR1C

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Full Name

Activin A Receptor Type 1C

Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Biological Process

Activin receptor signaling pathway
Apoptotic nuclear changes
Cell differentiation
Cellular response to growth factor stimulus
Lipid storage
Negative regulation of chorionic trophoblast cell proliferation
Negative regulation of insulin secretion
Negative regulation of trophoblast cell migration
Nervous system development
Nodal signaling pathway
Positive regulation of apoptotic process
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Protein phosphorylation
Response to dietary excess
Response to glucose
Response to insulin
Trophectodermal cell proliferation

Cellular Location

Membrane

Topology

Extracellular: 22-113 aa
Helical: 114-134 aa
Cytoplasmic: 135-493 aa