Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY)

Name: Mouse Anti-CARTPT Recombinant Antibody (113612)
SKU: CBMAB-C2450-LY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in WB

Representative capillary westerns showing the reactivity of the mouse anti-CARTp antibody against different amounts of synthetic CARTp and scrambled CARTp. ...View More

Kobori, N., Moore, A. N., Redell, J. B., & Dash, P. K. (2023). Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function. Journal of Neuroinflammation, 20(1), 158.

Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in IHC

nNOS-positive nerves (nNOS+ green) immunoreactive to cocaine- and amphetamine-regulated transcript (CART) (red) in the: (I) muscular layer of the corpus, (II) mucosal layer of the corpus, (III) muscular layer of the horns, (IV) mucosal layer of the horns of the uterine body of control animals (A) and pigs treated with low (B) and high (C) dose of bisphenol A. Nerves simultaneously immunoreactive to nNOS and CART (yellow) are indicated with arrowheads. ...View More

Rytel, L., & Gonkowski, S. (2020). The influence of bisphenol a on the nitrergic nervous structures in the domestic porcine uterus. International Journal of Molecular Sciences, 21(12), 4543.

Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in IHC

Triple staining of the neuronal marker UCHL1 and two different TRPV1 antibodies derived from rabbit and goat, respectively, to facilitate the analysis of various targets. The staining intensities obtained with both TRPV1 antibodies correlated significantly (Spearmans ρ = 0.96, p<2.2e-16). Co-labeling of TRPV1 and CART. ...View More

Isensee, J., Wenzel, C., Buschow, R., Weissmann, R., Kuss, A. W., & Hucho, T. (2014). Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS One, 9(12), e115731.

Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in IHC

Immunostaining for CART, Calbindin and Parvalbumin in a retinal sections of MTN injected mice. ...View More

Ruff, T., Peters, C., Matsumoto, A., Ihle, S. J., Morales, P. A., Gaitanos, L., ... & Klein, R. (2021). FLRT3 marks direction-selective retinal ganglion cells that project to the medial terminal nucleus. Frontiers in Molecular Neuroscience, 14, 790466.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

113612

Application

WB, IHC

Immunogen

E. coli-derived recombinant human CART, Ala37-Leu116.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml
IHC	8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CART Prepropeptide

Introduction

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]

Entrez Gene ID

9607

UniProt ID

Q16568

Alternative Names

CART Prepropeptide; CART; Cocaine- And Amphetamine-Regulated Transcript Protein; Cocaine And Amphetamine Regulated Transcript;

Function

Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.

Biological Process

Activation of MAPKK activity Source: HGNC-UCL
Adult feeding behavior Source: HGNC-UCL
Cell-cell signaling Source: ProtInc
Cellular glucose homeostasis Source: HGNC-UCL
Cellular response to starvation Source: HGNC-UCL
Chemical synaptic transmission Source: UniProtKB-KW
Circadian regulation of gene expression Source: HGNC-UCL
G protein-coupled receptor signaling pathway Source: HGNC-UCL
Negative regulation of appetite Source: HGNC-UCL
Negative regulation of bone resorption Source: HGNC-UCL
Negative regulation of glucagon secretion Source: Ensembl
Negative regulation of osteoclast differentiation Source: HGNC-UCL
Neuropeptide signaling pathway Source: UniProtKB-KW
Positive regulation of blood pressure Source: HGNC-UCL
Positive regulation of epinephrine secretion Source: HGNC-UCL
Positive regulation of transmission of nerve impulse Source: HGNC-UCL
Regulation of insulin secretion Source: Ensembl
Signal transduction Source: ProtInc
Somatostatin secretion Source: Ensembl

Cellular Location

Secreted

Mahmoudi-Nezhad, M., Farhangi, M. A., & Kahroba, H. (2020). Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals. Journal of translational medicine, 18(1), 1-10.

Khodarahmi, M., Farhangi, M., & Niknam, M. (2020). The interaction between dietary Non-Enzymatic Antioxidant Capacity (NEAC) and variant of Cocaine and Amphetamine-Regulated Transcript Prepropeptide (CARTPT) 5q13-14-rs2239670 locus on hypothalamic-pituitary axis hormones and metabolic risk factors in obese individuals.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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