CARTPT
This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]
Full Name
CART Prepropeptide
Function
Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
Biological Process
Activation of MAPKK activity Source: HGNC-UCL
Adult feeding behavior Source: HGNC-UCL
Cell-cell signaling Source: ProtInc
Cellular glucose homeostasis Source: HGNC-UCL
Cellular response to starvation Source: HGNC-UCL
Chemical synaptic transmission Source: UniProtKB-KW
Circadian regulation of gene expression Source: HGNC-UCL
G protein-coupled receptor signaling pathway Source: HGNC-UCL
Negative regulation of appetite Source: HGNC-UCL
Negative regulation of bone resorption Source: HGNC-UCL
Negative regulation of glucagon secretion Source: Ensembl
Negative regulation of osteoclast differentiation Source: HGNC-UCL
Neuropeptide signaling pathway Source: UniProtKB-KW
Positive regulation of blood pressure Source: HGNC-UCL
Positive regulation of epinephrine secretion Source: HGNC-UCL
Positive regulation of transmission of nerve impulse Source: HGNC-UCL
Regulation of insulin secretion Source: Ensembl
Signal transduction Source: ProtInc
Somatostatin secretion Source: Ensembl
Adult feeding behavior Source: HGNC-UCL
Cell-cell signaling Source: ProtInc
Cellular glucose homeostasis Source: HGNC-UCL
Cellular response to starvation Source: HGNC-UCL
Chemical synaptic transmission Source: UniProtKB-KW
Circadian regulation of gene expression Source: HGNC-UCL
G protein-coupled receptor signaling pathway Source: HGNC-UCL
Negative regulation of appetite Source: HGNC-UCL
Negative regulation of bone resorption Source: HGNC-UCL
Negative regulation of glucagon secretion Source: Ensembl
Negative regulation of osteoclast differentiation Source: HGNC-UCL
Neuropeptide signaling pathway Source: UniProtKB-KW
Positive regulation of blood pressure Source: HGNC-UCL
Positive regulation of epinephrine secretion Source: HGNC-UCL
Positive regulation of transmission of nerve impulse Source: HGNC-UCL
Regulation of insulin secretion Source: Ensembl
Signal transduction Source: ProtInc
Somatostatin secretion Source: Ensembl
Cellular Location
Secreted
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Anti-CARTPT antibodies
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Target: CARTPT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 113612
Application*: WB, IH
Target: CARTPT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-116
Tag: Fc Tag
Target: CARTPT
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-116
Target: CARTPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D6M2M
Application*: WB, P
Target: CARTPT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: D6L8J
Application*: IP, IF
Target: CARTPT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3E4
Application*: E, WB, IP
Target: CARTPT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 7C11
Application*: IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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