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Mouse Anti-EPO Recombinant Antibody (4G7) (CBMAB-A2672-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
EPO (NP_000790.2, 1 a.a. ~ 193 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Erythropoietin
Introduction
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq]
Entrez Gene ID
2056
UniProt ID
P01588
Alternative Names
EP; MGC138142
Research Area
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Biological Process
Acute-phase response Source: Ensembl
Aging Source: Ensembl
Apoptotic process Source: Ensembl
Blood circulation Source: ProtInc
Cellular hyperosmotic response Source: BHF-UCL
Embryo implantation Source: Ensembl
Erythrocyte differentiation Source: BHF-UCL
Erythrocyte maturation Source: UniProtKB-KW
Erythropoietin-mediated signaling pathway Source: UniProtKB
Hemoglobin biosynthetic process Source: Ensembl
Negative regulation of calcium ion transport into cytosol Source: BHF-UCL
Negative regulation of cation channel activity Source: BHF-UCL
Negative regulation of erythrocyte apoptotic process Source: BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: BHF-UCL
Negative regulation of neuron death Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of activated T cell proliferation Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of Ras protein signal transduction Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Response to axon injury Source: Ensembl
Response to dexamethasone Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to estrogen Source: Ensembl
Response to hyperoxia Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to salt stress Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin A Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Microvascular complications of diabetes 2 (MVCD2):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Erythrocytosis, familial, 5 (ECYT5):
An autosomal dominant disorder characterized by elevated serum hemoglobin and hematocrit. Some patients have increased serum erythropoietin levels.
Diamond-Blackfan anemia-like (DBAL):
An autosomal recessive hematologic disease characterized by severe red cell hypoplastic anemia, selective absence of red cell precursors and progenitors seen on bone marrow biopsy, and increased serum erythropoietin.
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For research use only. Not intended for any clinical use.

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