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Mouse Anti-EPPIN (AA 22-134) Recombinant Antibody (CBFYE-1077) (CBMAB-E1606-FY)

This product is mouse antibody that recognizes EPPIN. The antibody CBFYE-1077 can be used for immunoassay techniques such as: ELISA, WB.
See all EPPIN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1077
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa22-134 from human SPINLW1 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgM, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 22-134

Target

Full Name
Epididymal Peptidase Inhibitor
Introduction
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
57119
UniProt ID
O95925
Alternative Names
Epididymal Peptidase Inhibitor; Epididymal Protease Inhibitor; Serine Peptidase Inhibitor-Like, With Kunitz And WAP Domains 1 (Eppin); WAP Four-Disulfide Core Domain Protein 7; Cancer/Testis Antigen 71; Cancer/Testis Antigen 72; Protease Inhibitor WAP7; SPINLW1; WFDC7
Research Area
Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
Biological Process
Defense response to bacterium Source: UniProtKB
Negative regulation of calcium ion import Source: UniProtKB
Negative regulation of flagellated sperm motility Source: UniProtKB
Negative regulation of peptidase activity Source: UniProtKB
Cellular Location
Isoform 1: Secreted; Cell surface. Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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