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Rabbit Anti-EPS15L1 (C-terminus) Recombinant Antibody (CBFYE-1080) (CBMAB-E1611-FY)

This product is rabbit antibody that recognizes EPS15L1. The antibody CBFYE-1080 can be used for immunoassay techniques such as: WB, IP, ICC, FC, IHC-P.
See all EPS15L1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYE-1080
Antibody Isotype
IgG
Application
WB, IP, ICC, FC, IHC-P

Basic Information

Immunogen
A synthetic peptide corresponding to residues near the C-terminus of human EPS15R was used as an immunogen
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% glycerol, 0.05% BSA
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1
Introduction
EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1) is a Protein Coding gene. Diseases associated with EPS15L1 include Split Hand-Split Foot Malformation and Split Foot. Among its related pathways are Listeria monocytogenes entry into host cells and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is EPS15.
Entrez Gene ID
58513
UniProt ID
Q9UBC2
Alternative Names
Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1; Eps15-Related Protein; EPS15R; Epidermal Growth Factor Receptor Pathway Substrate 15-Like 1; Epidermal Growth Factor Receptor Substrate 15-Like 1; Epidermal Growth Factor Receptor Substrate EPS15R
Research Area
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Biological Process
Endocytosis Source: GO_Central
Endosomal transport Source: GO_Central
Cellular Location
Nucleus; Cell membrane; Coated pit. Localized to plasma membrane coated pits.
PTM
Phosphorylated on tyrosine residues by EGFR.By similarity
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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