EPS15L1

EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1) is a Protein Coding gene. Diseases associated with EPS15L1 include Split Hand-Split Foot Malformation and Split Foot. Among its related pathways are Listeria monocytogenes entry into host cells and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is EPS15.

Full Name

Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1

Research Area

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Biological Process

Endocytosis Source: GO_Central
Endosomal transport Source: GO_Central

Cellular Location

Nucleus; Cell membrane; Coated pit. Localized to plasma membrane coated pits.

PTM

Phosphorylated on tyrosine residues by EGFR.By similarity