EPS15L1

EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1) is a Protein Coding gene. Diseases associated with EPS15L1 include Split Hand-Split Foot Malformation and Split Foot. Among its related pathways are Listeria monocytogenes entry into host cells and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is EPS15.

Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Endocytosis Source: GO_Central
Endosomal transport Source: GO_Central

Nucleus; Cell membrane; Coated pit. Localized to plasma membrane coated pits.

Phosphorylated on tyrosine residues by EGFR.By similarity