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Mouse Anti-GNA12 Recombinant Antibody (CBFYH-0402) (CBMAB-H1272-FY)

This product is mouse antibody that recognizes GNA12. The antibody CBFYH-0402 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all GNA12 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYH-0402
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
guanine nucleotide binding protein, alpha 12
Introduction
The GNA12 and PMS2 genes were examined in two affected (A1, A2) and two unaffected (U1, U2) subjects from a large 7p22‐linked FH‐II family (family 1). No mutations were found.
Entrez Gene ID
Human2768
Mouse14673
Rat81663
UniProt ID
HumanQ03113
MouseP27600
RatQ63210
Alternative Names
RMP; gep; NNX3
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452).

Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387).

GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity).

GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996).

Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452).

Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920).

Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433).

May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Blood coagulation Source: ProtInc
G protein-coupled receptor signaling pathway Source: ProtInc
Negative regulation of vascular associated smooth muscle cell migration Source: Ensembl
Negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Regulation of fibroblast migration Source: UniProtKB
Regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of TOR signaling Source: UniProtKB
Response to drug Source: Ensembl
Rho protein signal transduction Source: GO_Central
Cellular Location
Cell membrane; Lateral cell membrane; Cytoplasm. CDH1 enhances cell membrane localization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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