Rabbit Anti-EPS15L1 Recombinant Antibody (E1612) (V2LY-0825-LY559)

Name: Rabbit Anti-EPS15L1 Recombinant Antibody (E1612)
SKU: V2LY-0825-LY559
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

E1612

Application

WB, IP

Immunogen

Human EPS15R.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1

Entrez Gene ID

58513

UniProt ID

Q9UBC2

Research Area

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Biological Process

Endocytosis Source: GO_Central
Endosomal transport Source: GO_Central

Cellular Location

Nucleus; Cell membrane; Coated pit. Localized to plasma membrane coated pits.

PTM

Phosphorylated on tyrosine residues by EGFR.By similarity

Lu, H., Zhu, C., Chen, Y., Ruan, Y., Fan, L., Chen, Q., & Wei, Q. (2022). LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1/EGFR signaling pathway. Clinical and Translational Oncology, 24(6), 1124-1133.

Milesi, C., Alberici, P., Pozzi, B., Oldani, A., Beznoussenko, G. V., Raimondi, A., ... & Offenhäuser, N. (2019). Redundant and nonredundant organismal functions of EPS15 and EPS15L1. Life science alliance, 2(1).

Umair, M., Ullah, A., Abbas, S., Ahmad, F., Basit, S., & Ahmad, W. (2018). First direct evidence of involvement of a homozygous loss‐of‐function variant in the EPS15L1 gene underlying split‐hand/split‐foot malformation. Clinical Genetics, 93(3), 699-702.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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