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Mouse Anti-EPSTI1 Recombinant Antibody (2A8) (CBMAB-A2676-LY)

The product is antibody recognizes EPSTI1. The antibody 2A8 immunoassay techniques such as: WB, ELISA.
See all EPSTI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A8
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
EPSTI1 (NP_001002264, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
epithelial stromal interaction 1 (breast)
Entrez Gene ID
94240
UniProt ID
Q96J88
Alternative Names
BRESI1; MGC29634
Research Area
Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity).

Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).

Bei, Y. R., Zhang, S. C., Song, Y., Tang, M. L., Zhang, K. L., Jiang, M., ... & Hu, Y. W. (2022). EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression. Acta Pharmacologica Sinica, 1-10.

Adilijiang, K., Zhihua, M., Zhayidan, A., Ayinuerguli, A., Nadire, H., & Abulaiti, A. (2022). Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-kB signaling in a cellular pneumonia model. Allergol. immunopatol, 50(3), 106-112.

Sun, J. L., Zhang, H. Z., Liu, S. Y., Lian, C. F., Chen, Z. L., Shao, T. H., ... & Zhang, F. C. (2020). Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren’s syndrome. Annals of the Rheumatic Diseases, 79(4), 518-524.

Fan, M. M., Arai, M., Tawada, A., Chiba, T., Fukushima, R., Uzawa, K., ... & Takiguchi, Y. (2020). Contrasting functions of EPSTI1 in human oral and lung squamous cell cancer cell lines-its tumor promoting roles in oral and tumor suppressing roles in lung squamous cell carcinomas. Cancer Research, 80(16_Supplement), 2580-2580.

Xie, J., Wang, S., Li, G., Zhao, X., Jiang, F., Liu, J., & Tan, W. (2019). circEPSTI1 regulates ovarian cancer progression via decoying miR‐942. Journal of cellular and molecular medicine, 23(5), 3597-3602.

Kim, Y. H., Lee, J. R., & Hahn, M. J. (2018). Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1). Biochemical and biophysical research communications, 496(2), 778-783.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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