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Mouse Anti-EPSTI1 (AA 1-101) Recombinant Antibody (CBFYE-0247) (CBMAB-E0501-FY)

This product is mouse antibody that recognizes EPSTI1. The antibody CBFYE-0247 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all EPSTI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0247
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-101

Target

Full Name
epithelial stromal interaction 1 (breast)
Introduction
The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE).
Entrez Gene ID
94240
UniProt ID
Q96J88
Alternative Names
Epithelial Stromal Interaction 1; Epithelial Stromal Interaction 1 (Breast); Epithelial Stromal Interaction Protein 1; Epithelial-Stromal Interaction Protein 1; EC 3.1.4.16; EC 3.6.3.6; BRESI1
Research Area
Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity).

Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).

Bei, Y. R., Zhang, S. C., Song, Y., Tang, M. L., Zhang, K. L., Jiang, M., ... & Hu, Y. W. (2022). EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression. Acta Pharmacologica Sinica, 1-10.

Adilijiang, K., Zhihua, M., Zhayidan, A., Ayinuerguli, A., Nadire, H., & Abulaiti, A. (2022). Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-kB signaling in a cellular pneumonia model. Allergol. immunopatol, 50(3), 106-112.

Sun, J. L., Zhang, H. Z., Liu, S. Y., Lian, C. F., Chen, Z. L., Shao, T. H., ... & Zhang, F. C. (2020). Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren’s syndrome. Annals of the Rheumatic Diseases, 79(4), 518-524.

Fan, M. M., Arai, M., Tawada, A., Chiba, T., Fukushima, R., Uzawa, K., ... & Takiguchi, Y. (2020). Contrasting functions of EPSTI1 in human oral and lung squamous cell cancer cell lines-its tumor promoting roles in oral and tumor suppressing roles in lung squamous cell carcinomas. Cancer Research, 80(16_Supplement), 2580-2580.

Xie, J., Wang, S., Li, G., Zhao, X., Jiang, F., Liu, J., & Tan, W. (2019). circEPSTI1 regulates ovarian cancer progression via decoying miR‐942. Journal of cellular and molecular medicine, 23(5), 3597-3602.

Kim, Y. H., Lee, J. R., & Hahn, M. J. (2018). Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1). Biochemical and biophysical research communications, 496(2), 778-783.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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