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Mouse Anti-ERBIN Recombinant Antibody (10D2) (CBMAB-A2685-LY)

The product is antibody recognizes ERBB2IP. The antibody 10D2 immunoassay techniques such as: WB, ELISA.
See all ERBIN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10D2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ERBB2IP (NP_061165, 1272 a.a. ~ 1371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Erbb2 Interacting Protein
Introduction
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. [provided by RefSeq]
Entrez Gene ID
55914
UniProt ID
Q96RT1
Alternative Names
ERBIN; LAP2
Research Area
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728).

Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).
Biological Process
Basal protein localization Source: UniProtKB
Cell adhesion Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarity Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Intermediate filament cytoskeleton organization Source: UniProtKB
Negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: UniProtKB
Positive regulation of Ras protein signal transduction Source: GO_Central
Protein targeting Source: Ensembl
Regulation of postsynaptic membrane neurotransmitter receptor levels Source: Ensembl
Response to lipopolysaccharide Source: UniProtKB
Response to muramyl dipeptide Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Nucleus membrane; Basolateral cell membrane; Hemidesmosome. Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).

Şahin, F. (2022). Analysis of the effect of Erbin on the epithelial to mesenchymal transition related genes in breast cancer (Doctoral dissertation, Bilkent University).

Jang, H., Stevens, P., Gao, T., & Galperin, E. (2021). The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease. The FEBS journal, 288(3), 721-739.

Tan, Y., Lin, X. T., Luo, Y. D., Zhang, J., Fang, L., Zhu, Y. Y., ... & Xie, C. M. (2020). Reduced IκBα promotes hepatocellular carcinoma cell proliferation and migration via regulation of NF‑κB/Erbin axis. Oncology Letters, 20(5), 1-1.

Luo, Z. Y., Huang, L., Lin, S., Yin, Y. N., Jie, W., Hu, N. Y., ... & Gao, T. M. (2020). Erbin in amygdala parvalbumin-positive neurons modulates anxiety-like behaviors. Biological psychiatry, 87(10), 926-936.

Jin, X., Li, B., Zhao, Y., Liu, X., Li, Y., Song, L., ... & Guo, Y. (2019). Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway. Journal of Cellular Biochemistry, 120(3), 4654-4664.

Valenzuela-Iglesias, A., Burks, H. E., Arnette, C. R., Yalamanchili, A., Nekrasova, O., Godsel, L. M., & Green, K. J. (2019). Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent MannerDesmoglein 1 Suppresses Invadopodia and Matrix Degradation. Molecular Cancer Research, 17(5), 1195-1206.

Zhao, Y., Zhang, X., Wang, R., Bing, J., Wu, F., Zhang, Y., ... & Zeng, S. (2018). Erbin and ErbB2 play roles in the sexual differentiation of the song system nucleus HVC in bengalese finches (Lonchura Striata var. domestica). Developmental Neurobiology, 78(1), 15-38.

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For research use only. Not intended for any clinical use.

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