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Mouse Anti-ERCC1 Recombinant Antibody (3A7) (CBMAB-A2693-LY)

The product is antibody recognizes ERCC1. The antibody 3A7 immunoassay techniques such as: WB, ELISA.
See all ERCC1 antibodies
Published Data
Fig.1 EGFR gene amplification positive or negative and EGFR high or low by IHC.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3A7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ERCC1 (AAH52813, 207 a.a. ~ 281 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit
Entrez Gene ID
2067
UniProt ID
P07992
Alternative Names
COFS4; UV20
Research Area
Isoform 1:
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

Isoform 2:
Not functional in the nucleotide excision repair pathway.

Isoform 3:
Not functional in the nucleotide excision repair pathway.

Isoform 4:
Not functional in the nucleotide excision repair pathway.
Biological Process
Cell population proliferation Source: Ensembl
DNA recombination Source: MGI
DNA repair Source: MGI
Double-strand break repair via nonhomologous end joining Source: BHF-UCL
Embryonic organ development Source: Ensembl
Interstrand cross-link repair Source: Ensembl
Isotype switching Source: Ensembl
Male gonad development Source: Ensembl
Meiotic mismatch repair Source: GO_Central
Mitotic recombination Source: UniProtKB
Multicellular organism aging Source: Ensembl
Multicellular organism growth Source: Ensembl
Negative regulation of protection from non-homologous end joining at telomere Source: BHF-UCL
Negative regulation of telomere maintenance Source: UniProtKB
Nucleotide-excision repair Source: MGI
Nucleotide-excision repair, DNA incision, 3'-to lesion Source: UniProtKB
Nucleotide-excision repair, DNA incision, 5'-to lesion Source: UniProtKB
Oogenesis Source: Ensembl
Positive regulation of t-circle formation Source: BHF-UCL
Positive regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
Post-embryonic hemopoiesis Source: Ensembl
Pyrimidine dimer repair by nucleotide-excision repair Source: Ensembl
Replicative senescence Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to sucrose Source: Ensembl
Response to X-ray Source: Ensembl
Spermatogenesis Source: Ensembl
Syncytium formation Source: Ensembl
T-circle formation Source: BHF-UCL
Telomeric DNA-containing double minutes formation Source: BHF-UCL
UV-damage excision repair Source: GO_Central
UV protection Source: Ensembl
Cellular Location
Isoform 1&3&4: Nucleus
Isoform 2: Nucleus; Cytoplasm
Involvement in disease
Cerebro-oculo-facio-skeletal syndrome 4 (COFS4):
A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome.
PTM
Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages (PubMed:25538220). Deubiquitinated by USP45 (PubMed:25538220).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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