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Mouse Anti-ERCC1 Recombinant Antibody (CBFYE-1146) (CBMAB-E1707-FY)

This product is mouse antibody that recognizes ERCC1. The antibody CBFYE-1146 can be used for immunoassay techniques such as: IHC-P, WB.
Host Species
Mouse
Application
IHC-P, WB
Antibody Isotype
IgG2a
Cross Reactivity
Human
Clone
CBFYE-1146
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Alternative Name
ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit; Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1 (Includes Overlapping Antisense Sequence); Excision Repair Cross-Complementation Group 1; DNA Excision Repair Protein ERCC-1; COFS4; RAD10; UV20
Entrez Gene ID
UniProt ID
Cat CBMAB-E1707-FY
Conjugates
Size
Price $
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