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Rabbit Anti-KDELR2 Recombinant Antibody (EG1134) (CBMAB-EN1351-LY)

The product is antibody recognizes ERD22. The antibody EG1134 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000.
See all KDELR2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1134
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ERD22.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kdel Endoplasmic Reticulum Protein Retention Receptor 2
Entrez Gene ID
Human11014
Mouse66913
Rat304290
UniProt ID
HumanP33947
MouseQ9CQM2
RatQ5U305
Function
Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (PubMed:1325562, PubMed:18086916, PubMed:33053334).
Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Maintenance of protein localization in endoplasmic reticulumManual Assertion Based On ExperimentIMP:UniProtKB
Protein retention in ER lumenManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic vesicle, COPI-coated vesicle membrane. Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Involvement in disease
Osteogenesis imperfecta 21 (OI21):
An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI21 is a progressively deforming form characterized by multiple fractures appearing at birth or early childhood.
Topology
Lumenal: 1-4
Helical: 5-24
Cytoplasmic: 25-32
Helical: 33-52
Lumenal: 53-58
Helical: 59-79
Cytoplasmic: 80-92
Helical: 93-110
Lumenal: 111-116
Helical: 117-135
Cytoplasmic: 136-149
Helical: 150-168
Lumenal: 169-178
Helical: 179-199
Cytoplasmic: 200-212

Ma, S., Sa, L., Zhang, J., Jiang, K., Mi, B., & Shan, L. (2023). KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration. Genetics and Molecular Biology, 46, e20230002.

Meng, X., Li, W., Yuan, H., Dong, W., Xiao, W., & Zhang, X. (2022). KDELR2-KIF20A axis facilitates bladder cancer growth and metastasis by enhancing Golgi-mediated secretion. Biological Procedures Online, 24(1), 12.

Zhang, G., Wang, B., Cheng, S., Fan, H., Liu, S., Zhou, B., ... & Zhang, Y. (2021). KDELR2 knockdown synergizes with temozolomide to induce glioma cell apoptosis through the CHOP and JNK/p38 pathways. Translational Cancer Research, 10(7), 3491.

Wei, H., Ma, W., Lu, X., Liu, H., Lin, K., Wang, Y., ... & Zhong, X. (2021). KDELR2 promotes breast cancer proliferation via HDAC3‐mediated cell cycle progression. Cancer Communications, 41(9), 904-920.

Van Dijk, F. S., Semler, O., Etich, J., Köhler, A., Jimenez-Estrada, J. A., Bravenboer, N., ... & Micha, D. (2020). Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2. The American Journal of Human Genetics, 107(5), 989-999.

Mao, H., Nian, J., Wang, Z., Li, X., & Huang, C. (2020). KDELR2 is an unfavorable prognostic biomarker and regulates CCND1 to promote tumor progression in glioma. Pathology-Research and Practice, 216(7), 152996.

Bajaj, R., Kundu, S. T., Grzeskowiak, C. L., Fradette, J. J., Scott, K. L., Creighton, C. J., & Gibbons, D. L. (2020). IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. Oncogene, 39(37), 5979-5994.

Liao, Z., She, C., Ma, L., Sun, Z., Li, P., Zhang, X., ... & Li, W. (2019). KDELR2 promotes glioblastoma tumorigenesis targeted by HIF1a via mTOR signaling pathway. Cellular and Molecular Neurobiology, 39, 1207-1215.

Tiwarekar, V., Fehrholz, M., & Schneider-Schaulies, J. (2019). KDELR2 competes with measles virus envelope proteins for cellular chaperones reducing their chaperone-mediated cell surface transport. Viruses, 11(1), 27.

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For research use only. Not intended for any clinical use.

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