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Mouse Anti-ERRFI1 Recombinant Antibody (2B9) (CBMAB-A2712-LY)

The product is antibody recognizes ERRFI1. The antibody 2B9 immunoassay techniques such as: WB, ELISA.
See all ERRFI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ERRFI1 (NP_061821, 111 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ERBB receptor feedback inhibitor 1
Introduction
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM
Entrez Gene ID
54206
UniProt ID
Q9UJM3
Alternative Names
GENE-33; MIG-6; MIG6; RALT
Research Area
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
Biological Process
Cellular hyperosmotic response Source: Ensembl
Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to insulin stimulus Source: Ensembl
Cellular response to platelet-derived growth factor stimulus Source: Ensembl
Lung alveolus development Source: UniProtKB
Lung epithelium development Source: UniProtKB
Lung vasculature development Source: UniProtKB
Negative regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
Negative regulation of collagen biosynthetic process Source: Ensembl
Negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathway Source: GO_Central
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of interleukin-1 beta production Source: Ensembl
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: Ensembl
Regulation of keratinocyte differentiation Source: UniProtKB
Regulation of type B pancreatic cell proliferation Source: Ensembl
Skin morphogenesis Source: UniProtKB
Cellular Location
Nucleus; Cell membrane; Cytoplasm. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).

Wu, K., Chen, X., & Ma, S. (2022). EP05. 01-031 Lysimachia Capillipes Capilliposide C Enhances the Radiosensitivity of Lung Cancer by Promoting ERRFI1 via Inhibiting Phosphorylation of STAT3. Journal of Thoracic Oncology, 17(9), S281.

Xu, D., & Li, C. (2021). Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases. Cells, 10(7), 1574.

Yu, Y., Chen, Q., Zhang, X., Yang, J., Lin, K., Ji, C., ... & Miao, L. (2020). Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression. Cancer science, 111(7), 2297-2309.

Ma, P., Zhang, C., Huo, P., Li, Y., & Yang, H. (2020). A novel role of the miR‐152‐3p/ERRFI1/STAT3 pathway modulates the apoptosis and inflammatory response after acute kidney injury. Journal of biochemical and molecular toxicology, 34(9), e22540.

Pan, R., Cai, W., Sun, J., Yu, C., Li, P., & Zheng, M. (2020). Inhibition of KHSRP sensitizes colorectal cancer to 5‐fluoruracil through miR‐501‐5p‐mediated ERRFI1 mRNA degradation. Journal of Cellular Physiology, 235(2), 1576-1587.

Wang, M., Zhao, Y., Yu, Z. Y., Zhang, R. D., Li, S. A., Zhang, P., ... & Sun, H. W. (2020). Glioma exosomal microRNA-148a-3p promotes tumor angiogenesis through activating the EGFR/MAPK signaling pathway via inhibiting ERRFI1. Cancer cell international, 20(1), 1-16.

Wang, W., Zheng, Y., Wang, M., Yan, M., Jiang, J., & Li, Z. (2019). Exosomes derived miR-126 attenuates oxidative stress and apoptosis from ischemia and reperfusion injury by targeting ERRFI1. Gene, 690, 75-80.

Guo, Y., Tian, L., Liu, X., He, Y., Chang, S., & Shen, Y. (2019). ERRFI1 inhibits proliferation and inflammation of nucleus pulposus and is negatively regulated by miR-2355-5p in intervertebral disc degeneration. Spine, 44(15), E873-E881.

Migliore, C., Morando, E., Ghiso, E., Anastasi, S., Leoni, V. P., Apicella, M., ... & Giordano, S. (2018). miR‐205 mediates adaptive resistance to MET inhibition via ERRFI 1 targeting and raised EGFR signaling. EMBO molecular medicine, 10(9), e8746.

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For research use only. Not intended for any clinical use.

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