ERRFI1

ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM

Full Name

ERBB receptor feedback inhibitor 1

Research Area

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).

Biological Process

Cellular hyperosmotic response Source: Ensembl
Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to insulin stimulus Source: Ensembl
Cellular response to platelet-derived growth factor stimulus Source: Ensembl
Lung alveolus development Source: UniProtKB
Lung epithelium development Source: UniProtKB
Lung vasculature development Source: UniProtKB
Negative regulation of cardiac muscle hypertrophy in response to stress Source: Ensembl
Negative regulation of collagen biosynthetic process Source: Ensembl
Negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Negative regulation of epidermal growth factor receptor signaling pathway Source: GO_Central
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of interleukin-1 beta production Source: Ensembl
Negative regulation of protein autophosphorylation Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: Ensembl
Regulation of keratinocyte differentiation Source: UniProtKB
Regulation of type B pancreatic cell proliferation Source: Ensembl
Skin morphogenesis Source: UniProtKB

Cellular Location

Nucleus; Cell membrane; Cytoplasm. Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).