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Mouse Anti-ETFB Recombinant Antibody (CBFYE-1326) (CBMAB-E1934-FY)

This product is mouse antibody that recognizes ETFB. The antibody CBFYE-1326 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all ETFB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1326
Application
WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Electron Transfer Flavoprotein Beta Subunit
Introduction
This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Electron Transfer Flavoprotein Beta Subunit; Beta-ETF; Electron-Transferring-Flavoprotein, Beta Polypeptide; Electron-Transfer-Flavoprotein, Beta Polypeptide; Electron Transfer Flavoprotein, Beta Polypeptide; Electron Transfer Flavoprotein Subunit Beta; FP585; MADD
Research Area
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918).

It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128).

ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918).
Biological Process
Fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: UniProtKB
Cellular Location
Mitochondrion matrix
Involvement in disease
Glutaric aciduria 2B (GA2B):
An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.
PTM
Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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