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Mouse Anti-ETNK1 Recombinant Antibody (3F11) (CBMAB-A2723-LY)

The product is antibody recognizes ETNK1. The antibody 3F11 immunoassay techniques such as: WB, ELISA.
See all ETNK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F11
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ETNK1 (NP_061108, 133 a.a. ~ 228 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ethanolamine kinase 1
Introduction
This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
Entrez Gene ID
55500
UniProt ID
Q9HBU6
Alternative Names
EKI; EKI1; Nbla10396
Research Area
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
Biological Process
Phosphatidylethanolamine biosynthetic process Source: UniProtKB
Cellular Location
Cytoplasm

Lou, J., Liu, X., Fan, X., Xu, X., Wang, Z., & Wang, L. (2022). LncRNA FEZF1-AS1 negatively regulates ETNK1 to promote malignant progression of renal cell carcinoma. Journal of Medical Biochemistry.

Okuda, R., Nannya, Y., Ochi, Y., Creignou, M., Makishima, H., Yoshizato, T., ... & Ogawa, S. (2021). Der (1; 7)(q10; p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms. Blood, 138, 1513.

Xing, Y., Xu, C., Lin, X., Zhao, M., Gong, D., Liu, L., & Geng, T. (2021). Complement C3 participates in the development of goose fatty liver potentially by regulating the expression of FASN and ETNK1. Animal Science Journal, 92(1), e13527.

Fontana, D., Gambacorti-Passerini, C., & Piazza, R. (2021). Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage. Molecular & Cellular Oncology, 8(2), 1877598.

Fontana, D., Mauri, M., Renso, R., Docci, M., Crespiatico, I., Røst, L. M., ... & Piazza, R. (2020). ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine. Nature communications, 11(1), 1-16.

Fontana, D., Mauri, M., Renso, R., Docci, M., Crespiatico, I., Røst, L. M., ... & Gambacorti-Passerini, C. (2020). ETNK1 Mutations in Atypical Chronic Myeloid Leukemia Induce a Mutator Phenotype That Can be Reverted with Phosphoethanolamine. Blood, 136, LBA-5.

Li, L., Mou, Y. P., Wang, Y. Y., Wang, H. J., & Mou, X. Z. (2019). miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis. Pathology-Research and Practice, 215(9), 152511.

Fontana, D., Mauri, M., Niro, A., Massimino, L., Bertagna, M., Zambrotta, G., ... & Piazza, R. (2018). ETNK1 mutations promote ROS production and DNA damage through increased mitochondrial activity. Cancer Research, 78(13_Supplement), 3385-3385.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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