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Mouse Anti-ETNK1 (AA 133-229) Recombinant Antibody (CBFYE-0273) (CBMAB-E0552-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0273
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 133-229

Target

Full Name
ethanolamine kinase 1
Introduction
This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
55500
UniProt ID
Q9HBU6
Alternative Names
Ethanolamine Kinase 1; EKI 1; EKI1; Putative Protein Product Of Nbla10396; EC 2.7.1.82; Nbla10396; EKI
Research Area
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
Biological Process
Phosphatidylethanolamine biosynthetic process Source: UniProtKB
Cellular Location
Cytoplasm
More Infomation

Lou, J., Liu, X., Fan, X., Xu, X., Wang, Z., & Wang, L. (2022). LncRNA FEZF1-AS1 negatively regulates ETNK1 to promote malignant progression of renal cell carcinoma. Journal of Medical Biochemistry.

Okuda, R., Nannya, Y., Ochi, Y., Creignou, M., Makishima, H., Yoshizato, T., ... & Ogawa, S. (2021). Der (1; 7)(q10; p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms. Blood, 138, 1513.

Xing, Y., Xu, C., Lin, X., Zhao, M., Gong, D., Liu, L., & Geng, T. (2021). Complement C3 participates in the development of goose fatty liver potentially by regulating the expression of FASN and ETNK1. Animal Science Journal, 92(1), e13527.

Fontana, D., Gambacorti-Passerini, C., & Piazza, R. (2021). Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage. Molecular & Cellular Oncology, 8(2), 1877598.

Fontana, D., Mauri, M., Renso, R., Docci, M., Crespiatico, I., Røst, L. M., ... & Piazza, R. (2020). ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine. Nature communications, 11(1), 1-16.

Fontana, D., Mauri, M., Renso, R., Docci, M., Crespiatico, I., Røst, L. M., ... & Gambacorti-Passerini, C. (2020). ETNK1 Mutations in Atypical Chronic Myeloid Leukemia Induce a Mutator Phenotype That Can be Reverted with Phosphoethanolamine. Blood, 136, LBA-5.

Li, L., Mou, Y. P., Wang, Y. Y., Wang, H. J., & Mou, X. Z. (2019). miR-199a-3p targets ETNK1 to promote invasion and migration in gastric cancer cells and is associated with poor prognosis. Pathology-Research and Practice, 215(9), 152511.

Fontana, D., Mauri, M., Niro, A., Massimino, L., Bertagna, M., Zambrotta, G., ... & Piazza, R. (2018). ETNK1 mutations promote ROS production and DNA damage through increased mitochondrial activity. Cancer Research, 78(13_Supplement), 3385-3385.

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For research use only. Not intended for any clinical use.

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