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Recombinant Mouse Anti-ETS1 Recombinant Antibody (7F2) (CBMAB-XB0436-YC)

Provided herein is a Mouse Recombinant Antibody against ETS Proto-Oncogene 1, Transcription Factor. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all ETS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
7F2
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
(C)DEVARRWGKRKNKPK (Synthetic peptide corresponding to aa 368-382 of the human ETS-1)
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ETS Proto-Oncogene 1, Transcription Factor
Introduction
ETS1 is a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis.
Entrez Gene ID
Human2113
Mouse23871
UniProt ID
HumanP14921
MouseP27577
Alternative Names
ETS Proto-Oncogene 1, Transcription Factor; Avian Erythroblastosis Virus E26 (V-Ets) Oncogene Homolog-1; V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1; EWSR2; P54; V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 1;
Research Area
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Biological Process
Angiogenesis involved in wound healing Source: Ensembl
Cell differentiation Source: GO_Central
Cell motility Source: BHF-UCL
Cellular response to hydrogen peroxide Source: Ensembl
Estrous cycle Source: Ensembl
Female pregnancy Source: Ensembl
Hypothalamus development Source: Ensembl
Immune response Source: ProtInc
Negative regulation of cell cycle Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Pituitary gland development Source: Ensembl
PML body organization Source: BHF-UCL
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of cellular component movement Source: BHF-UCL
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of erythrocyte differentiation Source: UniProtKB
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: BHF-UCL
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of angiogenesis Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of extracellular matrix disassembly Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to antibiotic Source: UniProtKB
Response to estradiol Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to laminar fluid shear stress Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.
PTM
Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.By similarity
Ubiquitinated; which induces proteasomal degradation.By similarity

Juan, C., Zhu, Y., Chen, Y., Mao, Y., Zhou, Y., Zhu, W., ... & Wang, Q. (2022). Knocking down ETS Proto-oncogene 1 (ETS1) alleviates the pyroptosis of renal tubular epithelial cells in patients with acute kidney injury by regulating the NLR family pyrin domain containing 3 (NLRP3) transcription. Bioengineered, 13(5), 12927-12940.

Pan, G., Zhang, J., You, F., Cui, T., Luo, P., Wang, S., ... & Yuan, Q. (2022). ETS Proto-Oncogene 1-activated muskelin 1 antisense RNA drives the malignant progression of hepatocellular carcinoma by targeting miR-22-3p to upregulate ETS Proto-Oncogene 1. Bioengineered, 13(1), 1346-1358.

Mamoor, S. (2021). ETS proto-oncogene 1 transcription factor is differentially expressed in lymph node metastasis in human breast cancer.

Chen, Y., Wang, D., Shu, T., Sun, K., Zhao, J., Wang, M., ... & Yang, Z. (2021). Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway. Bioengineered, 12(2), 11410-11422.

Li, R., Dong, Y., & Li, F. (2021). ETS Proto-Oncogene 1 Suppresses MicroRNA-128 Transcription to Promote Osteogenic Differentiation Through the HOXA13/β-Catenin Axis. Frontiers in Physiology, 12, 626248.

Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N., ... & Li, J. (2021). miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1. Molecular medicine reports, 24(2), 1-9.

Teng, Y., Cang, B., Mao, F., Chen, W., Cheng, P., Peng, L., ... & Zhuang, Y. (2020). Expression of ETS1 in gastric epithelial cells positively regulate inflammatory response in Helicobacter pylori-associated gastritis. Cell death & disease, 11(7), 1-10.

Yalim‐Camci, I., Balcik‐Ercin, P., Cetin, M., Odabas, G., Tokay, N., Sayan, A. E., & Yagci, T. (2019). ETS1 is coexpressed with ZEB2 and mediates ZEB2‐induced epithelial‐mesenchymal transition in human tumors. Molecular carcinogenesis, 58(6), 1068-1081.

Xu, H., Zhao, G., Zhang, Y., Jiang, H., Wang, W., Zhao, D., ... & Qi, L. (2019). Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression. Journal of Experimental & Clinical Cancer Research, 38(1), 1-12.

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For research use only. Not intended for any clinical use.

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