ETS1

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

ETS Proto-Oncogene 1, Transcription Factor

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.

Angiogenesis involved in wound healing Source: Ensembl
Cell differentiation Source: GO_Central
Cell motility Source: BHF-UCL
Cellular response to hydrogen peroxide Source: Ensembl
Estrous cycle Source: Ensembl
Female pregnancy Source: Ensembl
Hypothalamus development Source: Ensembl
Immune response Source: ProtInc
Negative regulation of cell cycle Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Pituitary gland development Source: Ensembl
PML body organization Source: BHF-UCL
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of cellular component movement Source: BHF-UCL
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of erythrocyte differentiation Source: UniProtKB
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: BHF-UCL
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of angiogenesis Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of extracellular matrix disassembly Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to antibiotic Source: UniProtKB
Response to estradiol Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to laminar fluid shear stress Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Transcription by RNA polymerase II Source: UniProtKB

Nucleus; Cytoplasm. Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.

Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.By similarity
Ubiquitinated; which induces proteasomal degradation.By similarity