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Mouse Anti-EXOSC5 Recombinant Antibody (2E7) (CBMAB-A2759-LY)

The product is antibody recognizes EXOSC5. The antibody 2E7 immunoassay techniques such as: IF, ELISA.
See all EXOSC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7
Antibody Isotype
IgG2a, κ
Application
IF, ELISA

Basic Information

Immunogen
EXOSC5 (AAH07742.1, 1 a.a. ~ 235 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Exosome Component 5
Entrez Gene ID
56915
UniProt ID
Q9NQT4
Alternative Names
MGC111224; MGC12901; RRP41B; RRP46; Rrp46p; hRrp46p; p12B
Research Area
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Biological Process
Defense response to virus Source: MGI
DNA deamination Source: UniProtKB
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Nuclear mRNA surveillance Source: GO_Central
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: GO_Central
Polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
rRNA catabolic process Source: GO_Central
rRNA processing Source: UniProtKB
U4 snRNA 3'-end processing Source: GO_Central
Cellular Location
Nucleolus; Nucleus; Cytoplasm

Zhang, Y., Yang, X., Hu, Y., & Huang, X. (2022). Integrated Bioinformatic Investigation of EXOSCs in Hepatocellular Carcinoma Followed by the Preliminary Validation of EXOSC5 in Cell Proliferation. International Journal of Molecular Sciences, 23(20), 12161.

Chen, X., Huang, Y., Liu, J., Lin, W., Chen, C., Chen, Y., ... & Teng, L. (2022). EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways. Journal of Cancer, 13(5), 1456.

Calame, D. G., Herman, I., Fatih, J. M., Du, H., Akay, G., Jhangiani, S. N., ... & Miyake, C. Y. (2021). Risk of sudden cardiac death in EXOSC5‐related disease. American Journal of Medical Genetics Part A, 185(8), 2532-2540.

Pan, H., Pan, J., Song, S., Ji, L., Lv, H., & Yang, Z. (2021). Corrigendum: EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways. Frontiers in Oncology, 11, 670041.

Slavotinek, A., Misceo, D., Htun, S., Mathisen, L., Frengen, E., Foreman, M., ... & Corbett, A. H. (2020). Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness. Human Molecular Genetics, 29(13), 2218-2239.

Schneidman-Duhovny, J. E. V., Duncan, J. L., Haaxma, C. A., Kamsteeg, E. J., Xia, V., Beleford, D., ... & Corbett, A. H. (2020). Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness Anne Slavotinek1,†,*, Doriana Misceo2,†, Stephanie Htun1, Linda Mathisen2, Eirik Frengen2, Michelle Foreman3, Jennifer E. Hurtig3, Liz Enyenihi4, Maria C. Sterrett4, Sara W. Leung4, Dina. Human Molecular Genetics, 29(13), 2218-2239.

Pan, H., Pan, J., Song, S., Ji, L., Lv, H., & Yang, Z. (2019). EXOSC5 as a novel prognostic marker promotes proliferation of colorectal cancer via activating the ERK and AKT pathways. Frontiers in oncology, 9, 643.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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