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Mouse Anti-F2RL3 Recombinant Antibody (CBXF-0162) (CBMAB-F1423-CQ)

This product is a mouse antibody that recognizes F2RL3. The antibody CBXF-0162 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all F2RL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0162
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Protease Activated Receptor 4
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F2R Like Thrombin Or Trypsin Receptor 3
Introduction
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients.
Entrez Gene ID
9002
UniProt ID
Q96RI0
Alternative Names
F2R Like Thrombin Or Trypsin Receptor 3; Coagulation Factor II (Thrombin) Receptor-Like 3; F2R Like Thrombin/Trypsin Receptor 3; Thrombin Receptor-Like 3; PAR-4; PAR4;
Research Area
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Biological Process
Blood coagulation Source: ProtInc
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Platelet activation Source: Reactome
Platelet dense granule organization Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of Rho protein signal transduction Source: GO_Central
Response to wounding Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 48-82
Helical: 83-103
Cytoplasmic: 104-108
Helical: 109-129
Extracellular: 130-151
Helical: 152-172
Cytoplasmic: 173-192
Helical: 193-213
Extracellular: 214-247
Helical: 248-268
Cytoplasmic: 269-283
Helical: 284-304
Extracellular: 305-319
Helical: 320-343
Cytoplasmic: 344-385
PTM
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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