F2RL3

This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

Full Name

F2R Like Thrombin Or Trypsin Receptor 3

Research Area

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Biological Process

Blood coagulation Source: ProtInc
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Platelet activation Source: Reactome
Platelet dense granule organization Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of Rho protein signal transduction Source: GO_Central
Response to wounding Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 48-82
Helical: 83-103
Cytoplasmic: 104-108
Helical: 109-129
Extracellular: 130-151
Helical: 152-172
Cytoplasmic: 173-192
Helical: 193-213
Extracellular: 214-247
Helical: 248-268
Cytoplasmic: 269-283
Helical: 284-304
Extracellular: 305-319
Helical: 320-343
Cytoplasmic: 344-385

PTM

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.