Human F2RL3 ELISA Kit (V2LY-0626-LY5727)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.045 ng/mL
Detection Range
0.1-40 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
41.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
F2R Like Thrombin Or Trypsin Receptor 3
Research Area
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Biological Process
Blood coagulation Source: ProtInc
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Platelet activation Source: Reactome
Platelet dense granule organization Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: GO_Central
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of Rho protein signal transduction Source: GO_Central
Response to wounding Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 48-82
Helical: 83-103
Cytoplasmic: 104-108
Helical: 109-129
Extracellular: 130-151
Helical: 152-172
Cytoplasmic: 173-192
Helical: 193-213
Extracellular: 214-247
Helical: 248-268
Cytoplasmic: 269-283
Helical: 284-304
Extracellular: 305-319
Helical: 320-343
Cytoplasmic: 344-385
PTM
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., van den Bosch, M. T., ... & Timpson, N. J. (2022). Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function. Circulation research, 130(3), 384-400.

Cao, D., Qu, Y., Zhang, X., Xu, F., Zhou, S., Zhang, G., ... & Zhao, J. (2018). High expression of F2RL3 correlates with aggressive features and poor survival in clear cell renal cell carcinoma. Journal of Cancer, 9(18), 3400.

Alhamdow, A., Lindh, C., Hagberg, J., Graff, P., Westberg, H., Krais, A. M., ... & Broberg, K. (2018). DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons. Carcinogenesis, 39(7), 869-878.

Gao, B. F., Shen, Z. C., Bian, W. S., Wu, S. X., Kang, Z. X., & Gao, Y. (2018). Correlation of hypertension and F2RL3 gene methylation with Prognosis of coronary heart disease. Journal of Biological Regulators and Homeostatic Agents, 32(6), 1539-1544.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Mouse Anti-F2RL3 Recombinant Antibody (CBXF-0162) (CAT#: V2LY-0825-LY1107)

Isotype control

For research use only. Not intended for any clinical use.

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