Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-FAIM2 Recombinant Antibody (V2-613348) (CBMAB-A2814-LY)


See all FAIM2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-613348
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FAIM2 (AAH00051, 1 a.a. ~ 316 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fas apoptotic inhibitory molecule 2
Entrez Gene ID
23017
UniProt ID
Q9BWQ8
Alternative Names
KIAA0950; LFG; NGP35; NMP35; TMBIM2
Research Area
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
Biological Process
Apoptotic process Source: UniProtKB-KW
Cerebellar granular layer development Source: UniProtKB
Cerebellar Purkinje cell differentiation Source: UniProtKB
Cerebellar Purkinje cell layer development Source: UniProtKB
Cerebellum development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
Negative regulation of neuron apoptotic process Source: Ensembl
Regulation of neuron apoptotic process Source: UniProtKB
Response to ischemia Source: Ensembl
Cellular Location
Cell membrane; Postsynaptic cell membrane; Membrane raft
More Infomation

Pan, Y., Zhang, Y., Tang, W., & Zhang, Y. (2020). Interstitial serum albumin empowers osteosarcoma cells with FAIM2 transcription to obtain viability via dedifferentiation. In Vitro Cellular & Developmental Biology-Animal, 56(2), 129-144.

Hong, C. J., Yeon, J., Yeo, B. K., Woo, H., An, H. K., Heo, W., ... & Yu, S. W. (2020). Fas‐apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome‐lysosome fusion through the LC3 interaction region motif–dependent interaction with LC3. The FASEB Journal, 34(1), 161-179.

Chen, Q., Lin, G., Huang, J., Chen, L., Liu, Y., Huang, J., ... & Lin, Q. (2020). Inhibition of miR-193a-3p protects human umbilical vein endothelial cells against intermittent hypoxia-induced endothelial injury by targeting FAIM2. Aging (Albany NY), 12(2), 1899.

Sawicka, B., Borysewicz-Sańczyk, H., Wawrusiewicz-Kurylonek, N., Aversa, T., Corica, D., Gościk, J., ... & Bossowski, A. (2020). Analysis of polymorphisms rs7093069-IL-2Ra, rs7138803-FAIM2, and rs1748033-PADI4 in the group of adolescents with autoimmune thyroid diseases. Frontiers in Endocrinology, 11, 544658.

Wang, M., Wang, Z., Zhu, X., Guan, S., & Liu, Z. (2019). NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1. In Vitro Cellular & Developmental Biology-Animal, 55(7), 491-500.

She, K., Yan, H., Huang, J., Zhou, H., & He, J. (2018). miR‐193b availability is antagonized by Lnc RNA‐SNHG 7 for FAIM 2‐induced tumour progression in non‐small cell lung cancer. Cell proliferation, 51(1), e12406.

Komnig, D., Gertz, K., Habib, P., Nolte, K. W., Meyer, T., Brockmann, M. A., ... & Reich, A. (2018). Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia. Journal of neurochemistry, 145(3), 258-270.

Shen, W., Liu, J., Fan, M., Wang, S., Zhang, Y., Wen, L., ... & Zhao, G. (2018). MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: an in vivo and in vitro study. Experimental Cell Research, 362(2), 370-377.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FAIM2 Recombinant Antibody (V2-613348)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry