FAIM2

FAIM2 (Fas Apoptotic Inhibitory Molecule 2) is a Protein Coding gene. Among its related pathways are Regulation by c-FLIP. An important paralog of this gene is TMBIM1.

Full Name

Fas apoptotic inhibitory molecule 2

Research Area

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

Biological Process

Apoptotic process Source: UniProtKB-KW
Cerebellar granular layer development Source: UniProtKB
Cerebellar Purkinje cell differentiation Source: UniProtKB
Cerebellar Purkinje cell layer development Source: UniProtKB
Cerebellum development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
Negative regulation of neuron apoptotic process Source: Ensembl
Regulation of neuron apoptotic process Source: UniProtKB
Response to ischemia Source: Ensembl

Cellular Location

Cell membrane; Postsynaptic cell membrane; Membrane raft