Mouse Anti-GLP1R Recombinant Antibody (4F3) (CBMAB-G0521-LY)

Name: Mouse Anti-GLP1R Recombinant Antibody (4F3)
SKU: CBMAB-G0521-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4F3

Application

ELISA, IHC, WB

Immunogen

Glucagon-like peptide-1 (7-36) peptide

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

15 mM sodium azide

Concentration

1.03 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glucagon like peptide 1 receptor

Introduction

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Entrez Gene ID

2740

UniProt ID

P43220

Alternative Names

Glucagon Like Peptide 1 Receptor; Glucagon-Like Peptide 1 Receptor; GLP-1 Receptor; GLP-1-R; GLP-1R; Seven Transmembrane Helix Receptor; GLP1 Receptor; GLP-1;

Function

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).

Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).

Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

Biological Process

Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
cAMP-mediated signaling Source: UniProtKB
Cell surface receptor signaling pathway Source: InterPro
Positive regulation of blood pressure Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 24-139
Helical: 140-164
Cytoplasmic: 165-175
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 266-290
Extracellular: 291-305
Helical: 306-328
Cytoplasmic: 329-348
Helical: 349-370
Extracellular: 371-383
Helical: 384-404
Cytoplasmic: 405-463

PTM

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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