GLP1R

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Full Name
glucagon like peptide 1 receptor
Function
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).

Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).

Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Biological Process
Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
cAMP-mediated signaling Source: UniProtKB
Cell surface receptor signaling pathway Source: InterPro
Positive regulation of blood pressure Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-139
Helical: 140-164
Cytoplasmic: 165-175
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 266-290
Extracellular: 291-305
Helical: 306-328
Cytoplasmic: 329-348
Helical: 349-370
Extracellular: 371-383
Helical: 384-404
Cytoplasmic: 405-463
PTM
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
View more

Anti-GLP1R antibodies

+ Filters
Loading...

Mouse Anti-GLP1R Recombinant Antibody (4F3) (CBMAB-G0521-LY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F3
Application*: E, IH, WB
Datasheet SDS

Rabbit Anti-GLP1R Recombinant Antibody (EG1330) (CBMAB-EN1608-LY)

Go to compareCompare
Target: GLP1R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1330
Application*: IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS

Mouse Anti-GLP1R (AA 1-37) Recombinant Antibody (CBFYH-3448) (CBMAB-H3995-FY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3448
Application*: E, WB
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (CBFYH-3446) (CBMAB-H3993-FY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3446
Application*: E
Datasheet SDS

Mouse Anti-GLP1R (AA 9-18) Recombinant Antibody (CBFYH-3357) (CBMAB-H0520-FY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3357
Application*: WB, E
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (419208) (CBMAB-G3830-LY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 419208
Application*: IH
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (4) (CBMAB-G3829-LY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4
Application*: E, IC, IF
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (CBLG1-125) (CBMAB-G0523-LY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-125
Application*: E
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (CBLG1-124) (CBMAB-G0522-LY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-124
Application*: E
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (CBFYH-0389) (CBMAB-H1261-FY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0389
Application*: P
Datasheet SDS

Mouse Anti-GLP1R Recombinant Antibody (CBFYH-0388) (CBMAB-H0371-FY)

Go to compareCompare
Target: GLP1R
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0388
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry