GLP1R
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Full Name
glucagon like peptide 1 receptor
Function
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).
Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).
Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Biological Process
Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
cAMP-mediated signaling Source: UniProtKB
Cell surface receptor signaling pathway Source: InterPro
Positive regulation of blood pressure Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-139
Helical: 140-164
Cytoplasmic: 165-175
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 266-290
Extracellular: 291-305
Helical: 306-328
Cytoplasmic: 329-348
Helical: 349-370
Extracellular: 371-383
Helical: 384-404
Cytoplasmic: 405-463
PTM
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
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Datasheet