Sign in or Register   Sign in or Register
  |  

Rabbit Anti-GLP1R Recombinant Antibody (EG1330) (CBMAB-EN1608-LY)

The product is antibody recognizes GLP1R. The antibody EG1330 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:5000.
See all GLP1R antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1330
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GLP1R.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glucagon like peptide 1 receptor
Introduction
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
Human2740
Mouse14652
UniProt ID
HumanP43220
MouseO35659
Alternative Names
GLP-1; GLP-1R; GLP-1-R
Function
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).

Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449).

Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Biological Process
Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
cAMP-mediated signaling Source: UniProtKB
Cell surface receptor signaling pathway Source: InterPro
Positive regulation of blood pressure Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-139
Helical: 140-164
Cytoplasmic: 165-175
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 176-201
Extracellular: 202-227
Helical: 228-251
Cytoplasmic: 252-265
Helical: 266-290
Extracellular: 291-305
Helical: 306-328
Cytoplasmic: 329-348
Helical: 349-370
Extracellular: 371-383
Helical: 384-404
Cytoplasmic: 405-463
PTM
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-GLP1R Recombinant Antibody (EG1330)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare