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Rabbit Anti-ENO2 Recombinant Antibody (BA0013) (CBMAB-0272CQ)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
BA0013
Application
WB, IHC, IF
Immunogen
Synthetic peptide within human nse aa 30-70.
Host Species
Rabbit
Specificity
Human, Mouse, Rat, Zebrafish
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000-1:5,000
IF(ICC)1:50-1:100
IHC-P1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, glycerol, BSA
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Enolase 2
Introduction
This gene encodes one of the three enolase isoenzymes found in mammals. The functional enzyme is a dimer made up of subunits referred to as alpha, beta, and gamma. In mammals there are at least 3 isoforms of enolase characterized by different tissue distrll as by distinct biochemical and immunologic properties. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Muller et al. (2012) showed that short hairpin RNA-mediated silencing of ENO2 selectively inhibits growth, survival, and the tumorigenic potential of ENO1-deleted GBM cells, and that the enolase inhibitor phosphonoacetohydroxamate is selectively toxic to ENO1-deleted GBM cells relative to ENO1-intact GBM cells or normal astrocytes. Muller et al. (2012) suggested that the principle of collateral vulnerability should be applicable to other passenger-deleted genes encoding functionally redundant essential activities and provide an effective treatment strategy for cancers containing such genomic events.
Entrez Gene ID
Human2026
Mouse13807
UniProt ID
HumanP09104
MouseP17183
Alternative Names
Enolase 2; Enolase 2 (Gamma, Neuronal); 2-Phospho-D-Glycerate Hydro-Lyase; Neuronal Enriched Enolase; Neuron-Specific Enolase; Neural Enolase; EC 4.2.1.11; NSE; Epididymis Secretory Protein Li 279; 2-Phospho-D-Glycerate Hydrolyase; Neuron Specific Gamma Enolase; Neurone-Specific Enolase; Gamma-Enolase; HEL-S-279
Research Area
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
Biological Process
Glycolytic process Source: CAFA
Regulation of vacuole fusion, non-autophagic Source: GO_Central
Cellular Location
Cell membrane; Cytoplasm. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.

Yukimoto, R., Nishida, N., Hata, T., Fujino, S., Ogino, T., Miyoshi, N., ... & Eguchi, H. (2021). Specific activation of glycolytic enzyme enolase 2 in BRAF V600E‐mutated colorectal cancer. Cancer Science, 112(7), 2884-2894.

Sun, C., Liu, M., Zhang, W., Wang, S., Qian, G., Wang, M., & Zhang, G. (2021). Overexpression of enolase 2 is associated with worsened prognosis and increased glycikolysis in papillary renal cell carcinoma. Journal of Cellular Physiology, 236(5), 3821-3831.

Zheng, Y., Wu, C., Yang, J., Zhao, Y., Jia, H., Xue, M., ... & Dong, Q. (2020). Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer. Signal transduction and targeted therapy, 5(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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