Mouse Anti-FAIM2 Recombinant Antibody (CBXF-0270) (V2LY-0825-LY1302)

Name: Mouse Anti-FAIM2 Recombinant Antibody (CBXF-0270)
SKU: V2LY-0825-LY1302
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0270

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 1-72 mapping at the N-terminus of human FAIM2.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fas apoptotic inhibitory molecule 2

Entrez Gene ID

23017

UniProt ID

Q9BWQ8

Research Area

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

Biological Process

Apoptotic process Source: UniProtKB-KW
Cerebellar granular layer development Source: UniProtKB
Cerebellar Purkinje cell differentiation Source: UniProtKB
Cerebellar Purkinje cell layer development Source: UniProtKB
Cerebellum development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
Negative regulation of neuron apoptotic process Source: Ensembl
Regulation of neuron apoptotic process Source: UniProtKB
Response to ischemia Source: Ensembl

Cellular Location

Cell membrane; Postsynaptic cell membrane; Membrane raft

Pan, Y., Zhang, Y., Tang, W., & Zhang, Y. (2020). Interstitial serum albumin empowers osteosarcoma cells with FAIM2 transcription to obtain viability via dedifferentiation. In Vitro Cellular & Developmental Biology-Animal, 56(2), 129-144.

Hong, C. J., Yeon, J., Yeo, B. K., Woo, H., An, H. K., Heo, W., ... & Yu, S. W. (2020). Fas‐apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome‐lysosome fusion through the LC3 interaction region motif–dependent interaction with LC3. The FASEB Journal, 34(1), 161-179.

Chen, Q., Lin, G., Huang, J., Chen, L., Liu, Y., Huang, J., ... & Lin, Q. (2020). Inhibition of miR-193a-3p protects human umbilical vein endothelial cells against intermittent hypoxia-induced endothelial injury by targeting FAIM2. Aging (Albany NY), 12(2), 1899.

Sawicka, B., Borysewicz-Sańczyk, H., Wawrusiewicz-Kurylonek, N., Aversa, T., Corica, D., Gościk, J., ... & Bossowski, A. (2020). Analysis of polymorphisms rs7093069-IL-2Ra, rs7138803-FAIM2, and rs1748033-PADI4 in the group of adolescents with autoimmune thyroid diseases. Frontiers in Endocrinology, 11, 544658.

Wang, M., Wang, Z., Zhu, X., Guan, S., & Liu, Z. (2019). NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1. In Vitro Cellular & Developmental Biology-Animal, 55(7), 491-500.

She, K., Yan, H., Huang, J., Zhou, H., & He, J. (2018). miR‐193b availability is antagonized by Lnc RNA‐SNHG 7 for FAIM 2‐induced tumour progression in non‐small cell lung cancer. Cell proliferation, 51(1), e12406.

Komnig, D., Gertz, K., Habib, P., Nolte, K. W., Meyer, T., Brockmann, M. A., ... & Reich, A. (2018). Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia. Journal of neurochemistry, 145(3), 258-270.

Shen, W., Liu, J., Fan, M., Wang, S., Zhang, Y., Wen, L., ... & Zhao, G. (2018). MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: an in vivo and in vitro study. Experimental Cell Research, 362(2), 370-377.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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