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Mouse Anti-FAM3B Recombinant Antibody (1E7) (CBMAB-A2820-LY)

The product is antibody recognizes FAM3B. The antibody 1E7 immunoassay techniques such as: WB, ELISA.
See all FAM3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
FAM3B (AAH57829.1, 1 a.a. ~ 235 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
family with sequence similarity 3, member B
Entrez Gene ID
54097
UniProt ID
P58499
Alternative Names
2-21; C21orf11; C21orf76; ORF9; PANDER; PRED44
Research Area
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
Biological Process
Apoptotic process Source: UniProtKB-KW
Glucose homeostasis Source: InterPro
Insulin secretion Source: UniProtKB
Cellular Location
Secreted. Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
PTM
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.By similarity

Wang, W., Wang, M., Ahmed, M. M. S., Zhao, Y., Wu, H., Musa, M., & Chen, X. (2022). FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus. International Journal of General Medicine, 15, 763.

Zhang, F., Zhu, X., Wang, P., He, Q., Huang, H., Zheng, T., ... & Ding, Y. (2021). The cytokine FAM3B/PANDER is an FGFR ligand that promotes posterior development in Xenopus. Proceedings of the National Academy of Sciences, 118(20), e2100342118.

Song, C., & Duan, C. (2020). Upregulation of FAM3B promotes cisplatin resistance in gastric cancer by inducing epithelial-mesenchymal transition. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e921002-1.

Manya, H., Kuwabara, N., Kato, R., & Endo, T. (2020). FAM3B/PANDER-like carbohydrate-binding domain in a glycosyltransferase, POMGnT1. In Lectin Purification and Analysis (pp. 609-619). Humana, New York, NY.

Chi, Y., Meng, Y., Wang, J., Yang, W., Wu, Z., Li, M., ... & Yang, J. (2019). FAM3B (PANDER) functions as a co‐activator of FOXO1 to promote gluconeogenesis in hepatocytes. Journal of cellular and molecular medicine, 23(3), 1746-1758.

He, S. L., Wang, W. P., Yang, Y. S., Li, E. M., Xu, L. Y., & Chen, L. Q. (2019). FAM3B promotes progression of oesophageal carcinoma via regulating the AKT–MDM2–p53 signalling axis and the epithelial‐mesenchymal transition. Journal of Cellular and Molecular Medicine, 23(2), 1375-1385.

Lanka, G., Bathula, R., Dasari, M., Nakkala, S., Bhargavi, M., Somadi, G., & Potlapally, S. R. (2019). Structure-based identification of potential novel inhibitors targeting FAM3B (PANDER) causing type 2 diabetes mellitus through virtual screening. Journal of Receptors and Signal Transduction, 39(3), 253-263.

Maciel-Silva, P., Caldeira, I., de Assis Santos, I., Carreira, A. C. O., Siqueira, F. R., Antonioli, E., ... & Garay-Malpartida, H. M. (2018). FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-XL cell survival genes. BMC cancer, 18(1), 1-15.

Caldeira, I. D. (2018). Role of FAM3B/PANDER in inhibition of cell death and tumor growth in breast and prostate cancer. Cancer Research, 78(13_Supplement), 4380-4380.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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