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Mouse Anti-FAM3C Recombinant Antibody (CBYC-P066) (CBMAB-P0338-YC)

Provided herein is a Mouse monoclonal antibody against Human Family With Sequence Similarity 3 Member C. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all FAM3C antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYC-P066
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human ILEI (aa 42-227)
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Family With Sequence Similarity 3 Member C
Introduction
FAM3C is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells.
Entrez Gene ID
Human10447
Mouse27999
UniProt ID
HumanQ92520
MouseQ91VU0
Alternative Names
Family With Sequence Similarity 3 Member C; Interleukin-Like EMT Inducer; Interleukin-Like Epithelial-Mesenchymal Transition Inducer; Predicted Osteoblast Protein; ILEI; Family With Sequence Similarity 3, Member C; Protein FAM3C; GS3786;
Research Area
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Biological Process
Negative regulation of gluconeogenesis Source: InterPro
Cellular Location
Secreted; Cytoplasmic vesicle. Cytoplasmic in some cancer cells.

Watanabe, N., Nakano, M., Mitsuishi, Y., Hara, N., Mano, T., Iwata, A., ... & Nishimura, M. (2022). Transcriptional downregulation of FAM3C/ILEI in the Alzheimer’s brain. Human molecular genetics, 31(1), 122-132.

Nakano, M., Imamura, R., Sugi, T., & Nishimura, M. (2022). Human FAM3C restores memory-based thermotaxis of Caenorhabditis elegans famp-1/m70. 4 loss-of-function mutants. PNAS Nexus.

Zhu, Y., Pu, Z., Wang, G., Li, Y., Wang, Y., Li, N., & Peng, F. (2021). FAM3C: an emerging biomarker and potential therapeutic target for cancer. Biomarkers in Medicine, 15(5), 373-384.

Schmidt, U., Heller, G., Timelthaler, G., Heffeter, P., Somodi, Z., Schweifer, N., ... & Csiszar, A. (2021). The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness. Journal of Experimental & Clinical Cancer Research, 40(1), 1-21.

Nakano, M., Mitsuishi, Y., Liu, L., Watanabe, N., Hibino, E., Hata, S., ... & Nishimura, M. (2021). Extracellular release of ILEI/FAM3C and amyloid-β is associated with the activation of distinct synapse subpopulations. Journal of Alzheimer's Disease, 80(1), 159-174.

Song, Q., Song, J., Li, C., Wang, Y., Qi, L., & Wang, H. (2021). Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children. Pediatric Research, 89(3), 673-678.

Yang, W., Feng, B., Meng, Y., Wang, J., Geng, B., Cui, Q., ... & Yang, J. (2019). FAM3C‐YY1 axis is essential for TGFβ‐promoted proliferation and migration of human breast cancer MDA‐MB‐231 cells via the activation of HSF1. Journal of cellular and molecular medicine, 23(5), 3464-3475.

Wu, C. C., Xiao, Y., Li, H., Mao, L., Deng, W. W., Yu, G. T., ... & Sun, Z. J. (2019). Overexpression of FAM3C is associated with poor prognosis in oral squamous cell carcinoma. Pathology-Research and Practice, 215(4), 772-778.

Shi, M., Duan, G., Nie, S., Shen, S., & Zou, X. (2018). Elevated FAM3C promotes cell epithelial–mesenchymal transition and cell migration in gastric cancer. OncoTargets and therapy, 11, 8491.

Yin, S., Chen, F., Ye, P., & Yang, G. (2018). Overexpression of FAM3C protein as a novel biomarker for epithelial-mesenchymal transition and poor outcome in gastric cancer. International Journal of Clinical and Experimental Pathology, 11(8), 4247.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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