Sign in or Register   Sign in or Register
  |  

Mouse Anti-FAM49B Recombinant Antibody (SPM257) (CBMAB-F2993-CQ)

This product is a mouse antibody that recognizes FAM49B. The antibody SPM257 can be used for immunoassay techniques such as: IF, IHC-P.
See all FAM49B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
SPM257
Antibody Isotype
IgG2a, κ
Application
IF, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
family with sequence similarity 49, member B
Introduction
FAM49B (Family With Sequence Similarity 49 Member B) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is FAM49A.
Entrez Gene ID
51571
UniProt ID
Q9NUQ9
Alternative Names
Family With Sequence Similarity 49 Member B; L1; Family With Sequence Similarity 49, Member B; MTSS1/FAM49B Fusion; FAM49B/JPH1 Fusion; Protein FAM49B; BM-009;
Research Area
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061).

Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061).

Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585).

Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity).

Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164).
Biological Process
Cellular response to molecule of bacterial origin Source: UniProtKB
Negative regulation of actin filament polymerization Source: UniProtKB
Negative regulation of small GTPase mediated signal transduction Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of memory T cell activation Source: UniProtKB
Positive regulation of T cell activation Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: UniProtKB
Regulation of cell migration Source: UniProtKB
Regulation of chemotaxis Source: UniProtKB
Regulation of establishment of cell polarity Source: UniProtKB
Regulation of mitochondrial fission Source: UniProtKB
Cellular Location
Mitochondrion; Membrane
PTM
Ubiquitinated at Lys-74 upon Salmonella bacterial infection.

Huang, Z., Pu, J., Luo, Y., Fan, J., Li, K., Peng, D., ... & Zhou, F. (2022). FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner. Molecular Immunology, 143, 135-146.

Chen, Y., Jiang, Y., Lao, J., Zhou, Y., Su, L., & Huang, X. (2022). Characterization and Functional Study of FAM49B Reveals Its Effect on Cell Proliferation in HEK293T Cells. Genes, 13(2), 388.

Xu, F., Chen, J., & Huang, D. (2022). Pan-cancer analysis identifies FAM49B as an immune-related prognostic maker for hepatocellular carcinoma. Journal of Cancer, 13(1), 278.

Park, C. S., Guan, J., Rhee, P., Gonzalez, F., Coscoy, L., Robey, E. A., ... & Sadegh-Nasseri, S. (2022). Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes. bioRxiv.

Li, Y., Xiong, Y., Wang, Z., Han, J., Shi, S., He, J., ... & Liu, W. (2021). FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway. Cancer Cell International, 21(1), 1-20.

Zhang, Y., Du, P., Li, Y., Zhu, Q., Song, X., Liu, S., ... & Liu, Y. (2020). TASP1 promotes gallbladder cancer cell proliferation and metastasis by up-regulating FAM49B via PI3K/AKT pathway. International journal of biological sciences, 16(5), 739.

Li, W. R., Guan, X. L., Jiang, S., & Sun, L. (2020). The novel fish miRNA pol-miR-novel_171 and its target gene FAM49B play a critical role in apoptosis and bacterial infection. Developmental & Comparative Immunology, 106, 103616.

Kaplan, E., Stone, R., Hume, P. J., Greene, N. P., & Koronakis, V. (2020). Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly. Acta Crystallographica Section D: Structural Biology, 76(10), 1015-1024.

Chattaragada, M. S., Riganti, C., Sassoe, M., Principe, M., Santamorena, M. M., Roux, C., ... & Novelli, F. (2018). FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Oncogene, 37(6), 697-709.

Shang, W., Jiang, Y., Boettcher, M., Ding, K., Mollenauer, M., Liu, Z., ... & Wang, H. (2018). Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. Proceedings of the National Academy of Sciences, 115(17), E4051-E4060.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FAM49B Recombinant Antibody (SPM257)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare