FAM49B

FAM49B (Family With Sequence Similarity 49 Member B) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is FAM49A.

Full Name

family with sequence similarity 49, member B

Research Area

Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061).

Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061).

Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585).

Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity).

Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164).

Biological Process

Cellular response to molecule of bacterial origin Source: UniProtKB
Negative regulation of actin filament polymerization Source: UniProtKB
Negative regulation of small GTPase mediated signal transduction Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of memory T cell activation Source: UniProtKB
Positive regulation of T cell activation Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: UniProtKB
Regulation of cell migration Source: UniProtKB
Regulation of chemotaxis Source: UniProtKB
Regulation of establishment of cell polarity Source: UniProtKB
Regulation of mitochondrial fission Source: UniProtKB

Cellular Location

Mitochondrion; Membrane

PTM

Ubiquitinated at Lys-74 upon Salmonella bacterial infection.