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Mouse Anti-COL12A1 Recombinant Antibody (CBYY-C3117) (CBMAB-C4560-YY)

This product is mouse antibody that recognizes COL12A1. The antibody CBYY-C3117 can be used for immunoassay techniques such as: ELISA, IHC-Fr, IP, WB
See all COL12A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Chicken, Cattle
Clone
CBYY-C3117
Antibody Isotype
IgG1
Application
ELISA, IHC-Fr, IP, WB

Basic Information

Immunogen
Collagen type XII purified from bovine kidney
Specificity
Human, Mouse, Rat, Chicken, Cattle
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Collagen Type XII Alpha 1 Chain
Entrez Gene ID
Human1303
Mouse12816
Rat25683
Chicken395875
Cattle359712
UniProt ID
HumanQ99715
MouseQ60847
RatP70560
ChickenP13944
CattleP25508
Alternative Names
Cystathionine-Beta-Synthase; Serine Sulfhydrase; Beta-Thionase; EC 4.2.1.22; Cystathionine Beta-Synthase; Methylcysteine Synthase; HIP4;
Function
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
Biological Process
Cell adhesion Source: UniProtKB-KW
Collagen fibril organization Source: Reactome
Endodermal cell differentiation Source: UniProtKB
Cellular Location
Extracellular matrix
Involvement in disease
Ullrich congenital muscular dystrophy 2 (UCMD2):
A form of Ullrich muscular dystrophy, a congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
Bethlem myopathy 2 (BTHLM2):
A form of Bethlem myopathy, a benign proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles. BTHLM2 inheritance is autosomal dominant.
PTM
The triple-helical tail is stabilized by disulfide bonds at each end.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
Isoform 1 O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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