Mouse Anti-GluRIIA Monoclonal Antibody (8B4D2) (CBMAB-0305-CN)

Name: Mouse Anti-GluRIIA Monoclonal Antibody (8B4D2)
SKU: CBMAB-0305-CN
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-GluRIIA Monoclonal Antibody (8B4D2) (CBMAB-0305-CN) in IHC

(A-E) The GluRII staining of NMJs in muscle 4 of the A2 segment in CS, pdm31 and wg
mutants. The pattern and density of GluRII is not altered by loss of Pdm3 (A,B) but the
cluster-like GluRII pattern disappears in wgts/wgcx4 boutons compared to controls (C-E).
Scale bars: 10 µm ...View More

Kim, Y., & Cho, K. O. (2020). POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila. Scientific reports, 10(1), 517. https://doi.org/10.1038/s41598-020-57425-9

Mouse Anti-GluRIIA Monoclonal Antibody (8B4D2) (CBMAB-0305-CN) in IHC

(A-D) Synaptic boutons labelled for DLG (red) and GluRIIA (green) at NMJs between muscles 6/7. (A) Wild type; (B) gluIIA/Df; (C) staur9/Df; (D) stauHL/Df. ...View More

Gardiol, A., & St Johnston, D. (2014). Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. Developmental biology, 392(2), 153-167. https://doi.org/10.1016/j.ydbio.2014.06.007

Mouse Anti-GluRIIA Monoclonal Antibody (8B4D2) (CBMAB-0305-CN) in IF

(A-E) Confocal images of synaptic boutons labelled for DLG (blue), GluRIIA (red) and Coracle (green). (A) Coracle localises around the periphery of the NMJ just outside the ring of DLG that surrounds the GluRIIA clusters (B) Expression of cora-RNAi in muscle 12 (m12) abolishes the Coracle signal around the NMJ and in the cytoplasm of this muscle. (C) Coracle localises normally around the boutons in a gluRIIA null mutant. Note the strong Coracle signal in muscle 12 (m12). Coracle antibody strongly stains trachea (arrowhead) and glia (arrow). (D-E) Coracle localisation around the NMJ is strongly reduced in staur9/Df (D) and stauHL/Df (E). Scale bar (A: 8 µ; B, C: 12 µm; D, E: 15 µm). ...View More

Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8B4D2

Application

IF, IHC, WB

Immunogen

DGluR-IIA (aa 633-786)-6X-His-fusion protein.

Specificity

Common fruit fly

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

None

Concentration

Batch dependent

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GluRIIA

Introduction

The gene Glutamate receptor IIA is a protein_coding_gene from Drosophila melanogaster. It has one annotated transcript and one polypeptide. Gene sequence location is 2L:5555072..5558994. It has the cytological map location 25E6.

Entrez Gene ID

33788

UniProt ID

Q9VMP4

Alternative Names

CG6992; D-GluRIIA; DGluR-II; dglur-IIA; DGluR-IIA; DGluR2a; dGluRII; DgluRII; dglurIIA; dGluRIIA; DGluRIIa; DGluRIIA; DmelGluRIIA; Dmel\CG6992; Glu-RII; Glu-RIIA; gluIIA; GluR; GluR-IIA; GluR2; GluR2a; GluRII; GluRII-A; gluriia; glurIIA; gluRIIA; GlurIIA; GluRIIa; GluR[[IIa]]

Biological Process

Calcium ion transport Source: FlyBase
Chemical synaptic transmission Source: FlyBase
Modulation of chemical synaptic transmission Source: GO_Central
Neuromuscular synaptic transmission Source: FlyBase
Positive regulation of neuromuscular synaptic transmission Source: FlyBase
Regulation of neurotransmitter secretion Source: FlyBase
Regulation of synaptic activity Source: FlyBase
Synapse maturation Source: FlyBase
Synaptic transmission, glutamatergic Source: FlyBase

Cellular Location

Membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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