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Rabbit Anti-FANCA Recombinant Antibody (CBXF-1141) (CBMAB-F0800-CQ)

This product is a rabbit antibody that recognizes FANCA. The antibody CBXF-1141 can be used for immunoassay techniques such as: WB, IP, FC, IF.
See all FANCA antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1141
Antibody Isotype
IgG
Application
WB, IP, FC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fanconi Anemia Complementation Group A
Introduction
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.
Entrez Gene ID
2175
UniProt ID
O15360
Alternative Names
Fanconi Anemia Complementation Group A; FANCH; FACA; FAA; Fanconi Anemia, Complementation Group H; Fanconi Anemia Group A Protein; Fanconi Anemia, Type 1;
Research Area
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Biological Process
DNA repair Source: ProtInc
Female gonad development Source: Ensembl
Interstrand cross-link repair Source: InterPro
Male gonad development Source: Ensembl
Male meiotic nuclear division Source: Ensembl
Protein-containing complex assembly Source: ProtInc
Regulation of CD40 signaling pathway Source: Ensembl
Regulation of cell population proliferation Source: Ensembl
Regulation of DNA-binding transcription factor activity Source: Ensembl
Regulation of inflammatory response Source: Ensembl
Regulation of regulatory T cell differentiation Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Involvement in disease
Fanconi anemia, complementation group A (FANCA):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
PTM
Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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