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Mouse Anti-FBXL21 Recombinant Antibody (CBXF-0383) (CBMAB-F0351-CQ)

This product is a mouse antibody that recognizes FBXL21. The antibody CBXF-0383 can be used for immunoassay techniques such as: ELISA, WB.
See all FBXL21 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0383
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-box and leucine-rich repeat protein 21
Introduction
This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins.
Entrez Gene ID
26223
UniProt ID
Q9UKT6
Alternative Names
F-Box And Leucine Rich Repeat Protein 21 (Gene/Pseudogene); F-Box And Leucine-Rich Repeat Protein 21; F-Box And Leucine-Rich Repeat Protein 3 Pseudogene; F-Box And Leucine-Rich Repeat Protein 3B; F-Box/LRR-Repeat Protein 3B; FBXL3B; FBXL3P;
Research Area
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).
Biological Process
Entrainment of circadian clock by photoperiod Source: UniProtKB
G2/M transition of mitotic cell cycle Source: GO_Central
Protein ubiquitination Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Rhythmic process Source: UniProtKB-KW
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Cellular Location
Nucleus; Cytosol. Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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