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Rabbit Anti-FEV Recombinant Antibody (EG1187) (CBMAB-EN1432-LY)

The product is antibody recognizes FEV. The antibody EG1187 immunoassay techniques such as: WB: 1:500~1:3000 ELISA: 1:40000.
See all FEV antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1187
Antibody Isotype
IgG
Application
WB: 1:500~1:3000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human FEV.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FEV, ETS Transcription Factor
Introduction
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Entrez Gene ID
54738
UniProt ID
Q99581
Alternative Names
FEV, ETS Transcription Factor; PC12 ETS Domain-Containing Transcription Factor 1; Fifth Ewing Variant Protein; FEV (ETS Oncogene Family); PET-1; FEV (Fifth Ewing Variant);
Research Area
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
Biological Process
Cell differentiation Source: GO_Central
Neuron fate specification Source: Ensembl
Neuron maturation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Sudden infant death syndrome (SIDS):
SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

Liang, Y. X., Liang, Y. K., Zou, Z. H., Zhuo, Y. J., Ye, J. H., Zhu, X. J., ... & Zhong, W. D. (2022). Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer. Disease Markers, 2022.

Saulnier, O., Guedri-Idjouadiene, K., Aynaud, M. M., Chakraborty, A., Bruyr, J., Pineau, J., ... & Dequiedt, F. (2021). ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion. Nucleic acids research, 49(9), 5038-5056.

Febres-Aldana, C. A., Krishnamurthy, K., Delgado, R., Kochiyil, J., Poppiti, R., & Medina, A. M. (2020). Prostatic carcinoma with neuroendocrine differentiation harboring the EWSR1-FEV fusion transcript in a man with the WRN G327X germline mutation: A new variant of prostatic carcinoma or a member of the Ewing sarcoma family of tumors?. Pathology-Research and Practice, 216(2), 152758.

Tsuda, Y., Dickson, B. C., Swanson, D., Sung, Y. S., Zhang, L., Meyers, P., ... & Antonescu, C. R. (2020). Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior. Genes, Chromosomes and Cancer, 59(5), 286-294.

Hsing, M., Wang, Y., Rennie, P. S., Cox, M. E., & Cherkasov, A. (2020). ETS transcription factors as emerging drug targets in cancer. Medicinal Research Reviews, 40(1), 413-430.

Qi, T., Qu, Q., Li, G., Wang, J., Zhu, H., Yang, Z., ... & Qu, J. (2020). Function and regulation of the PEA3 subfamily of ETS transcription factors in cancer. American journal of cancer research, 10(10), 3083.

Hou, C., McCown, C., Ivanov, D. N., & Tsodikov, O. V. (2020). Structural Insight into the DNA Binding Function of Transcription Factor ERF. Biochemistry, 59(47), 4499-4506.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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