Mouse Anti-FGF16 (AA 2-207) Recombinant Antibody (CBXF-2611) (CBMAB-F3039-CQ)

Name: Mouse Anti-FGF16 (AA 2-207) Recombinant Antibody (CBXF-2611)
SKU: CBMAB-F3039-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-2611

Antibody Isotype

IgG2b

Application

Basic Information

Immunogen

E. coli-derived recombinant human FGF-16, Ala2-Arg207

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Lyophilized from a 0.2 μm filtered solution in PBS with trehalose

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 2-207

Target

Full Name

Fibroblast Growth Factor 16

Introduction

This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion.

Entrez Gene ID

8823

UniProt ID

O43320

Alternative Names

Fibroblast Growth Factor 16; Metacarpal 4-5 Fusion; FGF-16; MF4;

Research Area

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Positive regulation of brown fat cell proliferation Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cell migration Source: GO_Central
Response to temperature stimulus Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Secreted

Involvement in disease

Metacarpal 4-5 fusion (MF4):
A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.

More Infomation

References

Huang, K., Liang, J. J., Lin, Y. Q., Zhu, J. J., Ma, J. Q., & Wang, Y. (2020). Molecular characterization of fibroblast growth factor-16 and its role in promoting the differentiation of intramuscular preadipocytes in goat. animal, 14(11), 2351-2362.

Huang, J., Wang, K., Shiflett, L. A., Brotto, L., Bonewald, L. F., Wacker, M. J., ... & Brotto, M. (2019). Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells. Cell Cycle, 18(24), 3562-3580.

Duan, Y., Wang, Y., Li, X., Mo, J., Guo, X., Li, C., ... & Ge, R. S. (2019). Fibroblast growth factor 16 stimulates proliferation but blocks differentiation of rat stem Leydig cells during regeneration. Journal of cellular and molecular medicine, 23(4), 2632-2644.

Elsy, M., Rowbotham, A., Lord, H., Isaacs, H. V., & Pownall, M. E. (2019). Xenopus laevis FGF16 activates the expression of genes coding for the transcription factors Sp5 and Sp5l. International Journal of Developmental Biology, 1-10.

Wang, J. (2018). Fibroblast growth factor-16 and acute doxorubicin cardiotoxicity: a target for early protection.

Wang, J., Xiang, B., Dolinsky, V. W., Kardami, E., & Cattini, P. A. (2018). Cardiac Fgf-16 expression supports cardiomyocyte survival and increases resistance to doxorubicin cytotoxicity. DNA and Cell Biology, 37(11), 866-877.

Wang, S., Li, Y., Jiang, C., & Tian, H. (2018). Fibroblast growth factor 9 subfamily and the heart. Applied microbiology and biotechnology, 102(2), 605-613.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-FGF16 Recombinant Antibody (CBXF-3339)

Mouse Anti-FGF16 Recombinant Antibody (CBXF-1663)

Mouse Anti-FGF16 Recombinant Antibody (CBXF-3337)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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