Mouse Anti-FIGN Recombinant Antibody (2F8) (CBMAB-A2989-LY)

Name: Mouse Anti-FIGN Recombinant Antibody (2F8)
SKU: CBMAB-A2989-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2F8

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

FIGN (NP_060556.2, 77 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Fidgetin, Microtubule Severing Factor

Entrez Gene ID

55137

UniProt ID

Q5HY92

Function

ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cytoplasmic microtubule organization Source: GO_Central

Cellular Location

Centrosome; Nucleus matrix. Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.

More Infomation

References

Li, J., Wu, F., Cheng, L., Zhang, J., Cha, C., Chen, L., ... & Guo, G. (2020). A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule‑severing function. Molecular medicine reports, 21(6), 2367-2374.

Matamoros, A. J., Tom, V. J., Wu, D., Rao, Y., Sharp, D. J., & Baas, P. W. (2019). Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism. Journal of Neuroscience, 39(11), 2011-2024.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-FIGN (AA 77-170) Recombinant Antibody (CBXF-3032)

Mouse Anti-FIGN Recombinant Antibody (CBXF-1747)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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