FIGN

FIGN (Fidgetin, Microtubule Severing Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and microtubule-severing ATPase activity. An important paralog of this gene is FIGNL2.

Fidgetin, Microtubule Severing Factor

ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cytoplasmic microtubule organization Source: GO_Central

Centrosome; Nucleus matrix. Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.