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Mouse Anti-CCDC6 Recombinant Antibody (CBXC-0106) (CBMAB-C5397-CQ)


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Published Data
CBMAB-C5397-CQ-1
Mouse Anti-CCDC6 Recombinant Antibody (CBXC-0106) (CBMAB-C5397-CQ) in Immunoblot
Knockout of FBW7 in DLD1 and HCT116 cells leads to accumulation of CCDC6 protein. DLD1 or HCT116 WT and FBW7 deleted cells were harvested, lysed, and immunoblotted for indicated proteins. ...View More
Liu, J., Tokheim, C., Lee, J. D., Gan, W., North, B. J., Liu, X. S., ... & Wei, W. (2021). Genetic fusions favor tumorigenesis through degron loss in oncogenes. Nature Communications, 12(1), 6704.
CBMAB-C5397-CQ-2
Mouse Anti-CCDC6 Recombinant Antibody (CBXC-0106) (CBMAB-C5397-CQ) in Immunoblot
Colorectal cancer (CRC) cells with FBW7-mutant exhibited relatively higher protein abundance of CCDC6, compared with those cells with WT FBW7. ...View More
Liu, J., Tokheim, C., Lee, J. D., Gan, W., North, B. J., Liu, X. S., ... & Wei, W. (2021). Genetic fusions favor tumorigenesis through degron loss in oncogenes. Nature Communications, 12(1), 6704.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0106
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IP

Basic Information

Immunogen
Recombinant CCDC6 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coiled-Coil Domain Containing 6
Introduction
CCDC6 (Coiled-Coil Domain Containing 6) is a Protein Coding gene. Diseases associated with CCDC6 include Thyroid Cancer, Nonmedullary, 1 and Differentiated Thyroid Carcinoma. Among its related pathways are Mesodermal Commitment Pathway and Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and structural constituent of cytoskeleton.
Entrez Gene ID
8030
UniProt ID
Q16204
Alternative Names
Coiled-Coil Domain Containing 6; Papillary Thyroid Carcinoma-Encoded Protein; D10S170; TST1; DNA Segment, Single Copy, Probe PH4 (Transforming Sequence, Thyroid-1; DNA Segment On Chromosome 10 (Unique) 170;
Cellular Location
Cytoplasm; Cytoskeleton. May be a cytoskeletal protein.
Involvement in disease
A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
More Infomation

Morra, F., Merolla, F., Marino, F. Z., Catalano, R., Franco, R., Chieffi, P., & Celetti, A. (2021). The tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis. Heliyon, e08399.

Jin, D., Huang, K., Peng, L., Xu, P., Dang, Y., Yang, J., ... & Zhang, G. (2021). Circular RNA circDNA2 upregulates CCDC6 expression to promote the progression and unfavorable prognosis of gastric cancer via miR-149-5p suppression. Molecular Therapy-Nucleic Acids.

Liu, Y., Li, K., Zhu, W. B., Zhang, H., Huang, W. T., Liu, X. C., ... & Hu, C. (2021). Suppression of CCDC6 sensitizes tumor to oncolytic virus M1. Neoplasia, 23(1), 158-168.

Tang, Y., Yang, J., Wang, Y., Tang, Z., Liu, S., & Tang, Y. (2020). MiR-19b-3p facilitates the proliferation and epithelial-mesenchymal transition, and inhibits the apoptosis of intrahepatic cholangiocarcinoma by suppressing coiled-coil domain containing 6. Archives of biochemistry and biophysics, 686, 108367.

Laxmi, A., Gupta, P., & Gupta, J. (2019). CCDC6, a gene product in fusion with different protoncogenes, as a potential chemotherapeutic target. Cancer Biomarkers, 24(4), 383-393.

Jia, M., Shi, Y., Li, Z., Lu, X., & Wang, J. (2019). MicroRNA-146b-5p as an oncomiR promotes papillary thyroid carcinoma development by targeting CCDC6. Cancer letters, 443, 145-156.

Morra, F., Merolla, F., D’Abbiero, D., Ilardi, G., Campione, S., Monaco, R., ... & Celetti, A. (2019). Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma. Lung Cancer, 135, 56-65.

Cerrato, A., Merolla, F., Morra, F., & Celetti, A. (2018). CCDC6: the identity of a protein known to be partner in fusion. International journal of cancer, 142(7), 1300-1308.

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For research use only. Not intended for any clinical use.

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