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Rabbit Anti-FOXE1 Recombinant Antibody (CBXF-1231) (CBMAB-F0202-CQ)

This product is a rabbit antibody that recognizes FOXE1. The antibody CBXF-1231 can be used for immunoassay techniques such as: WB, IP, IHC-P, IF.
See all FOXE1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1231
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Forkhead Box E1
Introduction
This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4.
Entrez Gene ID
2304
UniProt ID
O00358
Alternative Names
Forkhead Box E1; Thyroid Transcription Factor 2; Forkhead-Related Protein FKHL15; HNF-3/Fork Head-Like Protein 5; Forkhead Box Protein E2; FKHL15; FOXE2; TITF2; HFKH4;
Function
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Cell migration Source: UniProtKB
Cranial skeletal system development Source: Ensembl
Embryonic organ morphogenesis Source: UniProtKB
Hair follicle morphogenesis Source: UniProtKB
Hard palate development Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Pharynx development Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Soft palate development Source: UniProtKB
Thymus development Source: UniProtKB
Thyroid gland development Source: UniProtKB
Thyroid hormone generation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Bamforth-Lazarus syndrome (BLS):
A disease characterized by thyroid agenesis, cleft palate and choanal atresia.
Thyroid cancer, non-medullary, 4 (NMTC4):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
PTM
Phosphorylated.

Al-Darraji, M. N., Jasim, S. A., Salah Aldeen, O. D. A., Ghasemian, A., & Rasheed, M. (2022). The Effect of LL37 Antimicrobial Peptide on FOXE1 and lncRNA PTCSC 2 Genes Expression in Colorectal Cancer (CRC) and Normal Cells. Asian Pacific Journal of Cancer Prevention, 23(10), 3437-3442.

Acar, S., Gürsoy, S., Arslan, G., Nalbantoğlu, Ö., Hazan, F., Köprülü, Ö., ... & Özkan, B. (2022). Screening of 23 candidate genes by next-generation sequencing of patients with permanent congenital hypothyroidism: novel variants in TG, TSHR, DUOX2, FOXE1, and SLC26A7. Journal of Endocrinological Investigation, 1-14.

Lim, G., Widiapradja, A., Levick, S. P., McKelvey, K. J., Liao, X. H., Refetoff, S., ... & Clifton-Bligh, R. J. (2022). Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. Endocrinology, 163(12), bqac158.

Gandarilla-Esparza, D. D., Calleros-Rincón, E. Y., Macias, H. M., González-Delgado, M. F., Vargas, G. G., Sustaita, J. D., ... & Pérez-Morales, R. (2021). FOXE1 polymorphisms and chronic exposure to nitrates in drinking water cause metabolic dysfunction, thyroid abnormalities, and genotoxic damage in women. Genetics and Molecular Biology, 44.

Morillo-Bernal, J., Fernández, L. P., & Santisteban, P. (2020). FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. Endocrine-Related Cancer, 27(3), 137.

Dai, W., Meng, X., Mo, S., Xiang, W., Xu, Y., Zhang, L., ... & Cai, G. (2020). FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer. Cell Communication and Signaling, 18, 1-13.

Credendino, S. C., Moccia, C., Amendola, E., D’Avino, G., Di Guida, L., Clery, E., ... & De Vita, G. (2020). Foxe1 gene dosage affects thyroid cancer histology and differentiation in vivo. International journal of molecular sciences, 22(1), 25.

Liu, H., Chen, X., Lin, T., Chen, X., Yan, J., & Jiang, S. (2019). MicroRNA‐524‐5p suppresses the progression of papillary thyroid carcinoma cells via targeting on FOXE1 and ITGA3 in cell autophagy and cycling pathways. Journal of cellular physiology, 234(10), 18382-18391.

Ding, Z., Ke, R., Zhang, Y., Fan, Y., & Fan, J. (2019). FOXE1 inhibits cell proliferation, migration and invasion of papillary thyroid cancer by regulating PDGFA. Molecular and cellular endocrinology, 493, 110420.

Ma, J., Huang, X., Li, Z., Shen, Y., Lai, J., Su, Q., ... & Xu, J. (2019). FOXE1 supports the tumor promotion of Gli2 on papillary thyroid carcinoma by the Wnt/β‐catenin pathway. Journal of Cellular Physiology, 234(10), 17739-17748.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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