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Mouse Anti-GABRG2 Recombinant Antibody (331A12) (CBMAB-1551-CN)

This product is a mouse antibody that recognizes GABRG2 of human. The antibody 331A12 can be used for immunoassay techniques such as: ICC, IP.
See all GABRG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
331A12
Antibody Isotype
IgG2a
Application
ICC, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Gamma-Aminobutyric Acid Type A Receptor Gamma2 Subunit
Introduction
GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABRG2 is a gamma-aminobutyric acid (GABA) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures.
Entrez Gene ID
Human2566
Mouse14406
Rat29709
UniProt ID
HumanP18507
MouseP22723
RatP18508
Alternative Names
CAE2; ECA2; GEFSP3
Function
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725).

Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268).

The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).

The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750).

The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).

Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
Biological Process
Adult behavior Source: Ensembl
Cellular response to histamine Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Gamma-aminobutyric acid signaling pathway Source: GO_Central
Inhibitory synapse assembly Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Post-embryonic development Source: Ensembl
Regulation of membrane potential Source: GO_Central
Regulation of postsynaptic membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, GABAergic Source: BHF-UCL
Cellular Location
Postsynaptic cell membrane; Cell membrane; Dendrite; Cytoplasmic vesicle membrane
Involvement in disease
Developmental and epileptic encephalopathy 74 (DEE74):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE74 is an autosomal dominant form with onset in the first year of life.
Epilepsy, childhood absence 2 (ECA2):
A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Some individuals manifest febrile seizures. Absence seizures may either remit or persist into adulthood.
Febrile seizures, familial, 8 (FEB8):
Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
Generalized epilepsy with febrile seizures plus 3 (GEFS+3):
A rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. This disease combines febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
PTM
Glycosylated.By similarity
Palmitoylated by ZDHHC3/GODZ; required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses.By similarity
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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