Mouse Anti-GNA15 (AA 1-256) Recombinant Antibody (CBFYH-3453) (CBMAB-H4001-FY)

This product is mouse antibody that recognizes GNA15. The antibody CBFYH-3453 can be used for immunoassay techniques such as: WB.
See all GNA15 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-3453

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-256 of human GNA15 produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-256

Target

Full Name

G protein subunit alpha 15

Introduction

The gene encoding the promiscuously coupling Gα15 protein (Gna15) located in tandem just upstream, an arrangement conserved in the human genome (on chromosome 19p13.3).

Entrez Gene ID

2769

UniProt ID

P30679

Alternative Names

GNA16

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Biological Process

Action potential Source: GO_Central
Activation of phospholipase C activity Source: ProtInc
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB

Cellular Location

Heterotrimeric G-protein complex; Plasma membrane; Synapse

References

Zeng, B., Chen, Y., Chen, H., Zhao, Q., Sun, Z., Liu, D., ... & Xing, H. R. (2023). Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15. Pharmacological Research, 106660.

Li, M., Liu, Y., Liu, Y., Yang, L., Xu, Y., Wang, W., ... & Wang, C. (2021). Downregulation of GNA15 Inhibits Cell Proliferation via P38 MAPK Pathway and Correlates with Prognosis of Adult Acute Myeloid Leukemia With Normal Karyotype. Frontiers in Oncology, 11, 724435.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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