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Mouse Anti-GNB1 Recombinant Antibody (CBLG1-3196) (CBMAB-G4128-LY)

This product is antibody recognizes GNB1. The antibody CBLG1-3196 immunoassay techniques such as: WB.
See all GNB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-3196
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein Subunit Beta 1
Introduction
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Entrez Gene ID
2782
UniProt ID
P62873
Alternative Names
G Protein Subunit Beta 1; Transducin Beta Chain 1; Guanine Nucleotide Binding Protein (G Protein); Beta Polypeptide 1; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1; Beta Subunit; Signal-Transducing Proteins GS/GI; Testicular Tissue Protein Li 72; MRD42;
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Biological Process
Adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
Cardiac muscle cell apoptotic process Source: Ensembl
Cell population proliferation Source: Ensembl
Cellular response to catecholamine stimulus Source: BHF-UCL
Cellular response to hypoxia Source: Ensembl
Cellular response to prostaglandin E stimulus Source: BHF-UCL
G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Ras protein signal transduction Source: ProtInc
Retina development in camera-type eye Source: Ensembl
Sensory perception of taste Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cytosol; Extracellular exosome; Extracellular vesicle; Lysosomal membrane; Heterotrimeric G-protein complex; Photoreceptor outer segment membrane; Plasma membrane; Cell body; Cytoplasm; Dendrite; Membrane; Photoreceptor disc membrane; Photoreceptor inner segment; Synapse
Involvement in disease
Mental retardation, autosomal dominant 42 (MRD42):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD42 patients manifest global developmental delay commonly accompanied by hypotonia, seizures of various types, ophthalmological manifestations, and poor growth.
PTM
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.

Tang, W., Zhang, L., Li, J., & Guan, Y. (2022). AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1. Bioengineered, 13(3), 5638-5652.

Kang, N. (2022). Characterization of G Protein Subunit Beta 1 as Regulator of Tumour Initiating Cell Activity in Human Pancreatic Cancer (Doctoral dissertation).

Zheng, H., Ma, L., Gui, R., Lin, X., Ke, X., Jian, X., ... & Chen, Q. (2022). G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2. Journal of Virology, 96(12), e00494-22.

Da Silva, J. D., Costa, M. D., Almeida, B., Lopes, F., Maciel, P., & Teixeira-Castro, A. (2021). Case report: a novel GNB1 mutation causes global developmental delay with intellectual disability and behavioral disorders. Frontiers in Neurology, 12, 735549.

Ruengsinpinya, L., Murakami, T., Nakamura, E., Takahata, Y., Hata, K., Nakaminami, Y., ... & Nishimura, R. (2020). G protein subunit β1 is an important mediator of the late stage of endochondral ossification. Biochemical and biophysical research communications, 533(1), 90-96.

Fan, Z., Bai, Y., Zhang, Q., & Qian, P. (2020). CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR‐326/GNB1 axis. Environmental toxicology, 35(10), 1146-1156.

Endo, W., Ikemoto, S., Togashi, N., Miyabayashi, T., Nakajima, E., Hamano, S. I., ... & Haginoya, K. (2020). Phenotype–genotype correlations in patients with GNB1 gene variants, including the first three reported Japanese patients to exhibit spastic diplegia, dyskinetic quadriplegia, and infantile spasms. Brain and Development, 42(2), 199-204.

Murakami, T., Ruengsinpinya, L., Nakamura, E., Takahata, Y., Hata, K., Okae, H., ... & Nishimura, R. (2019). Cutting edge: G protein subunit β 1 negatively regulates NLRP3 inflammasome activation. The Journal of Immunology, 202(7), 1942-1947.

Colombo, S., Petri, S., Shalomov, B., Reddy, H. P., Tabak, G., Dhindsa, R. S., ... & Goldstein, D. B. (2019). G protein-coupled potassium channels implicated in mouse and cellular models of GNB1 Encephalopathy. BioRxiv, 697235.

Szczałuba, K., Biernacka, A., Szymańska, K., Gasperowicz, P., Kosińska, J., Rydzanicz, M., & Płoski, R. (2018). Novel GNB1 de novo mutation in a patient with neurodevelopmental disorder and cutaneous mastocytosis: clinical report and literature review. European journal of medical genetics, 61(3), 157-160.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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